1316004

Hydrocortisone

United States Pharmacopeia (USP) Reference Standard

• Synonyme(s) : 11β,17α,21-trihydroxypregn-4-ène-3,20-dione, 4-pregnène-11β,17α,21-triol-3,20-dione, Composé F de Kendall, Substance M de Reichstein
• Formule empirique (notation de Hill) : C₂₁H₃₀O₅
• Numéro CAS: 50-23-7
• Poids moléculaire : 362.46
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329750063
• MDL number: MFCD00011654
• Beilstein/REAXYS Number: 1354819
• eCl@ss: 25140904

Propriétés

• grade: pharmaceutical primary standard
• agency: USP
• API family: hydrocortisone
• manufacturer/tradename: USP
• mp: 211-214 °C (lit.)
• application(s): pharmaceutical; pharmaceutical (small molecule)
• format: neat
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI key: JYGXADMDTFJGBT-VWUMJDOOSA-N
• Gene Information: human ... NR3C1(2908)

Description

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydrocortisone USP reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare standard stock, standard, and system suitability solution for assay, identification, and performance test by liquid chromatography in accordance with the given below monographs of United States Pharmacopeia (USP) :

• Hydrocortisone Sodium Succinate for Injection
• Hydrocortisone Tablets
• Hydrocortisone Gel
• Hydrocortisone Lotion

Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na²⁺ retention potency.

Principal glucocorticoïde secrété par la glande cortico-surrénale.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mot-clé: Danger
• Codes de danger: H360Df,H373
• Mentions de précaution: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1A - STOT RE 2
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Organes cibles: Adrenal gland,Bone marrow