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V1255

Sigma-Aldrich

D-Valine

BioReagent, suitable for cell culture

Synonyme(s) :

(R)-α-Aminoisovaleric acid, D-2-Amino-3-methylbutanoic acid

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About This Item

Formule linéaire :
(CH3)2CHCH(NH2)CO2H
Numéro CAS:
640-68-6
Poids moléculaire :
117.15
Numéro Beilstein :
1721135
Numéro CE :
211-368-9
Numéro MDL:
MFCD00064219
Code UNSPSC :
12352209
ID de substance PubChem :
24900713
Nomenclature NACRES :
NA.75

Source biologique

synthetic (organic)

Gamme de produits

BioReagent

Forme

powder

Technique(s)

cell culture | mammalian: suitable

Pf

>295 °C (subl.) (lit.)

Conditions d'expédition

ambient

Température de stockage

room temp

Chaîne SMILES 

CC(C)[C@@H](N)C(O)=O

InChI

1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/s1

Clé InChI

KZSNJWFQEVHDMF-SCSAIBSYSA-N

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Description générale

L-Valine is an essential non-polar amino acid. D-Valine is the non-proteinogenic isomer of valine.

Application

D-Valine has been used as a supplement in:
  • Dulbecco′s modified Eagle′s medium (DMEM)/Nutrient Mixture F-12 Ham (F-12) for mice renal proximal tubule cell (RPTC) culture
  • endothelial cell growth medium MV2 for rat lung microvascular endothelial cell (RLMEC) culture
  • DMEM/F-12 for mouse tracheal epithelial cell (MTEC) culture

Actions biochimiques/physiologiques

D-Valine has a broad range of industrial applications such as semi-synthetic veterinary antibiotics, pharmaceutical drugs, and agricultural pesticides.
D-valine is used in cell culture as a selective inhibitor of cell proliferation, wherein it inhibits cells that lack the enzyme D-amino acid oxidase. Historically D-valine has been used to inhibit fibroblast growth while allowing selective growth of epithelial cells.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Hui Li et al.
PLoS pathogens, 14(1), e1006821-e1006821 (2018-01-05)
The highly pathogenic avian influenza (HPAI) H5N1 influenza virus has been a public health concern for more than a decade because of its frequent zoonoses and the high case fatality rate associated with human infections. Severe disease following H5N1 influenza
Elham Mohammadi et al.
Cell and tissue research, 362(3), 597-609 (2015-06-13)
Efficacy of therapeutic angiogenesis needs a comprehensive understanding of endothelial cell (EC) function and biological factors and cells that interplay with ECs. Stem cells are considered the key components of pro- and anti-angiogenic milieu in a wide variety of physiopathological
Ming Chen et al.
World journal of microbiology & biotechnology, 32(10), 171-171 (2016-08-28)
D-Valine is an important organic chiral source and has extensive industrial application, which is used as intermediate for the synthesis of agricultural pesticides, semi-synthetic veterinary antibiotics and pharmaceutical drugs. Its derivatives have shown great activity in clinical use, such as
V A Lazzaro et al.
Research communications in chemical pathology and pharmacology, 75(1), 39-48 (1992-01-01)
A selective cell culture medium, D-valine minimal essential medium (92 mg/l), has been developed to inhibit the proliferation of fibroblasts in cell culture (Gilbert & Migeon 1975). Substitution of D-valine for L-valine prevents fibroblast growth due to the absence of
S F Gilbert et al.
Cell, 5(1), 11-17 (1975-05-01)
A nutrient medium has been developed to enable the growth of normal epithelial cells while selectively inhibiting fibroblast proliferation. In this medium, D-valine is substituted for L-valine; and only those cells containing D-amino acid oxidase can convert the D-amino acid
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