SRP3146
Prokineticin-2 human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonyme(s) :
PK2, PROK2, Protein Bv8 homolog
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20 μG
322.00 CHF
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20 μG
322.00 CHF
About This Item
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32
Produits recommandés
Source biologique
human
Produit recombinant
expressed in E. coli
Essai
≥98% (HPLC)
≥98% (SDS-PAGE)
Forme
lyophilized
Poids mol.
8.8 kDa
Conditionnement
pkg of 20 μg
Technique(s)
cell culture | mammalian: suitable
Impuretés
<0.1 EU/μg endotoxin, tested
Couleur
white
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Informations sur le gène
human ... PROK2(60675)
Description générale
Prokineticin-2 (PK2) is a cysteine-rich secreted protein that is expressed in the testis and in lower levels of the small intestine. PK2 regulates various biological functions including gastrointestinal motility, angiogenesis and circadiam rhythms. It is closely related to EG-VEGF (Prokineticin-1) and binds to two orphan B-protein-coupled receptors termed PK-R1 and PK-R2. Recombinant human Prokineticin-2 is an 8.8 kDa protein consisting of 81 amino acid residues and ten cysteine residues that potentially form five intra-molecular disulfide bonds.It also contains completely conserved N-terminal hexapeptide sequence that is involved in biological activity.[1] PK2 is encoded by the gene mapped to human chromosome 3p13.[2]
Actions biochimiques/physiologiques
Prokineticin-2 (PK2) plays a vital role in regulation of various biological functions, such as gastrointestinal motility, angiogenesis and circadian rhythms. It is closely related to EG-VEGF (endocrine gland-derived vascular endothelial growth factor)/prokineticin-1 (PK1). PK1 and PK2 exert their function by interacting with two G protein-coupled receptors PKR1 and PKR2, respectively.[1][2][3] PK2 is a candidate gene for the pathogenesis of mood disorders.[2]
Séquence
AVITGACDKD SQCGGGMCCA VSIWVKSIRI CTPMGKLGDS CHPLTRKVPF FGRRMHHTCP CLPGLACLRT SFNRFICLAQ K
Forme physique
Lyophilized with no additives.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese population.
Kishi T, et al.
Neuromolecular Medicine, 11(2), 114-122 (2009)
Prokineticin 2 and circadian clock output.
Zhou Q Y and Cheng M Y
FEBS Journal, 272(22), 5703-5709 (2005)
Takatoshi Soga et al.
Biochimica et biophysica acta, 1579(2-3), 173-179 (2002-11-13)
Recent studies have identified two novel biofunctional proteins, termed prokineticin 1/EG-VEGF and prokineticin 2, which were mammalian homologues of mamba MIT1 and frog Bv8. Prokineticins have been demonstrated to exert their physiological functions through G-protein coupled receptors (GPCRs). In this
The prokineticins: a novel pair of regulatory peptides.
Zhou Q Y.
Molecular Interventions, 6(6), 330-330 (2006)
Clayton M Bullock et al.
Molecular pharmacology, 65(3), 582-588 (2004-02-24)
Prokineticins are cysteine-rich secreted proteins that regulate diverse biological processes, including gastrointestinal motility, angiogenesis, and circadian rhythms. Two closely related G protein-coupled receptors that mediate signal transduction of prokineticins have recently been cloned. The structural elements required for prokineticins' bioactivities
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