This product is not a sterile preparation. If the intended use, such as in cell culture, requires a sterile environment, then the stock solution would require filter sterilization. Typically, this is achieved by filtration through a 0.22 um membrane. Alternatively, product S9133 is a γ-irradiated, sterile powder. When reconstituted aseptically using sterile water, this product may be added directly to culture medium.
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https://www.sigmaaldrich.com/product/sigma/s9133
S5261
Sodium selenite
BioReagent, suitable for cell culture, ≥98%
Synonyme(s) :
Selenious acid, Sodium salt
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About This Item
Formule linéaire :
Na2SeO3
Numéro CAS:
Poids moléculaire :
172.94
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352205
ID de substance PubChem :
Nomenclature NACRES :
NA.75
Produits recommandés
Source biologique
synthetic (inorganic)
Niveau de qualité
Gamme de produits
BioReagent
Essai
≥98%
Forme
powder
Technique(s)
cell culture | mammalian: suitable
Pf
>350 °C (lit.)
Solubilité
water: 50 mg/mL, clear to very slightly hazy, colorless
Chaîne SMILES
[Na+].[Na+].[O-][Se]([O-])=O
InChI
1S/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2
Clé InChI
BVTBRVFYZUCAKH-UHFFFAOYSA-L
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Application
Sodium selenite is commonly used as a source of selenium in biological research, where selenium is an essential trace element that is normally provided by serum. Selenium is present in selenoproteins such as glutathione peroxidase and thioredoxin reductase, which contain the selenium analog of cysteine, selenocysteine. In particular, glutathione peroxidase has a role in detoxification in vivo as a scavenger of peroxides. Sodium selenite has been utilized in studies of cell proliferation and cancer research. It has been used to alter gene expression in HepG2 cells as analyzed by cDNA microarrays. Sodium selenite can inhibit zinc finger protein/DNA interactions. Sodium selenite has been shown to alter mitochondrial membrane potentials and thus potentially contribute to apoptosis.
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
Risques supp
Code de la classe de stockage
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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need filtration (0.2um) after preparation?
1 answer-
Helpful?
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How long does an aliquot of this product in water remain stable at -20 degrees Celsius?
1 answer-
As mentioned on the Product Datasheet, stock solutions of sodium selenite may be frozen. Working aliquots remain active for 30 days at 2-8 °C. The Datasheet can accessed in the DOCUMENTATION section under 'More Documents'. Please see the link below:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/245/224/s5261pis.pdfHelpful?
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What solvent do I need to use? DMSO OK?
1 answer-
This item is soluble in water at 50mg/mL. The solubility in DMSO as not been tested.
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