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H8631

Sigma-Aldrich

5-Hydroxymethyl-2′-deoxyuridine

≥95% (HPLC)

Synonyme(s) :

5-HMdU, HMdUdr

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About This Item

Formule empirique (notation de Hill) :
C10H14N2O6
Numéro CAS:
5116-24-5
Poids moléculaire :
258.23
Numéro CE :
225-848-0
Numéro MDL:
MFCD00047489
Code UNSPSC :
41106305
ID de substance PubChem :
24895526

Essai

≥95% (HPLC)

Forme

powder

Solubilité

water: 50 mg/mL, clear, colorless to very faintly yellow

Température de stockage

−20°C

Chaîne SMILES 

OCC1OC(CC1O)N2C=C(CO)C(=O)NC2=O

InChI

1S/C10H14N2O6/c13-3-5-2-12(10(17)11-9(5)16)8-1-6(15)7(4-14)18-8/h2,6-8,13-15H,1,3-4H2,(H,11,16,17)

Clé InChI

IPAVKOYJGUMINP-UHFFFAOYSA-N

Application

5-Hydroxymethyl-2′-deoxyuridine (HMdUdr) is a used as a marker for oxidative nucleic acid (DNA) damage. HMdUdr may be used as an antigen to create anti-HMdUdr antibodies.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
061M5059V
061M5059
100M5056V
100M5056
069K5058

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Jin Wang et al.
Analytical chemistry, 83(6), 2201-2209 (2011-02-18)
The purpose of our study was to develop suitable methods to quantify oxidative DNA lesions in the setting of transition metal-related diseases. Transition metal-driven Fenton reactions constitute an important endogenous source of reactive oxygen species (ROS). In genetic diseases with
S Mitchell Harman et al.
Free radical biology & medicine, 35(10), 1301-1309 (2003-11-11)
To assess novel liquid chromatography/mass spectrometric methods for measuring oxidative damage to nucleic acids and lipids, we compared urinary excretion of 8-hydroxy-2'-deoxyguanosine (8-OHdG), 5-hydroxymethyl-2'-deoxyuridine (5-OHmU), and 8-hydroxyguanosine (8-OxoG), and an isoprostane, 8-iso-prostaglandin F(2)alpha (IsopF(2)alpha) in 234 healthy men (n =
I Kato et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 11(2), 143-152 (2006-06-13)
Oxidative stress has been implicated in the pathogenesis of various chronic diseases, such as cancer, cardiovascular disease and inflammatory conditions, as well as in ageing. Although a number of markers are now available, little is known about the reliability of
Joshy Joseph et al.
Chemical communications (Cambridge, England), 46(42), 7872-7878 (2010-09-11)
The feature article is a review of the reaction of thymine in the one-electron oxidation of duplex DNA. Oxidation of DNA causes chemical reactions that result in remote damage (mutation) to a nucleobase. Normally this reaction occurs at guanine, but
L A Mooney et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 10(6), 641-648 (2001-06-13)
Oxidative DNA damage and antibodies to that damage have been implicated in lung, breast, and colorectal cancer. In this observational validation study, the relationship between anti-5-hydroxymethyl-2'-deoxyuridine (HMdU) autoantibody (aAb) and plasma micronutrients was assessed in 140 heavy smokers by ELISA.
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