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E4250

Sigma-Aldrich

(−)-Epinephrine

≥99% (HPLC), powder, adrenoceptor agonist

Synonyme(s) :

(−)-Adrenalin, (R)-(−)-3,4-Dihydroxy-α-(methylaminomethyl)benzyl alcohol, L-Adrenaline, L-Epinephrine

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About This Item

Formule linéaire :
(HO)2C6H3CH(OH)CH2NHCH3
Numéro CAS:
51-43-4
Poids moléculaire :
183.20
Numéro Beilstein :
2368277
Numéro CE :
200-098-7
Numéro MDL:
MFCD00002204
Code UNSPSC :
12352200
ID de substance PubChem :
24894545
Nomenclature NACRES :
NA.77

product name

(−)-Epinephrine,

Niveau de qualité

200

Pf

215 °C (dec.) (lit.)

Température de stockage

2-8°C

Chaîne SMILES 

CNC[C@H](O)c1ccc(O)c(O)c1

InChI

1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1

Clé InChI

UCTWMZQNUQWSLP-VIFPVBQESA-N

Informations sur le gène

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)
rat ... Adra1a(29412) , Adra2a(25083) , Adrb1(24925) , Adrb2(24176) , Drd1a(24316) , Drd2(24318)

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Actions biochimiques/physiologiques

Adrenoceptor agonist.

Caractéristiques et avantages

This compound is featured on the α1-Adrenoceptors, α2-Adrenoceptors and β-Adrenoceptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Reconstitution

This product is only slightly soluble in water. Other sources state that it is soluble at 2 mg/mL in DMSO. The product solubility is tested at 50 mg/mL in 0.5 M HCl. This stock concentration can be diluted further in a buffer or medium to the required final concentration. In general, culture medium is buffered such that the final pH is not effected. The compound will remain in solution.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301 + H331,H310

Classification des risques

Acute Tox. 2 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Anastasia Eskova et al.
Current biology : CB, 30(2), 298-303 (2020-01-07)
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Mohit Kumar et al.
The Journal of biological chemistry, 295(32), 11275-11291 (2020-06-20)
Cardiac myosin-binding protein-C (cMyBP-C) is highly phosphorylated under basal conditions. However, its phosphorylation level is decreased in individuals with heart failure. The necessity of cMyBP-C phosphorylation for proper contractile function is well-established, but the physiological and pathological consequences of decreased
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Journal of dairy science, 104(1), 1099-1110 (2020-11-10)
Heat stress (HS) has a significant economic impact on the global dairy industry. However, the mechanisms by which HS negatively affects metabolism and milk synthesis in dairy ewes are not well defined. This study evaluated the production and metabolic variables
Eun-Min Kim et al.
PLoS neglected tropical diseases, 13(4), e0006843-e0006843 (2019-04-04)
Clonorchis sinensis is a group I bio-carcinogen responsible for cholangiocarcinoma (CHCA) in humans. However, the mechanism by which C. sinensis promotes carcinogenesis is unclear. Using the human cholangiocyte line H69, we investigated cell proliferation and gap junction protein expression after
M A Velazquez et al.
Reproduction (Cambridge, England), 141(1), 91-103 (2010-10-12)
The hypothesis that high concentrations of IGF1 can impair embryo development was investigated in a bovine in vitro model to reflect conditions in polycystic ovary syndrome (PCOS) patients. Embryos were either cultured in the absence or presence of a physiological
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