As stated in the 'PROPERTIES' section, the recommended storage temperature for this product is 2–8 °C. Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/402/297/d5207dat.pdf
D5207
Doxycycline hyclate
powder, suitable for cell culture, BioReagent
Synonyme(s) :
Chlorhydrate de doxycycline hémiéthanolate hémihydrate
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Sélectionner une taille de conditionnement
1 G
74.20 CHF
5 G
186.00 CHF
10 G
315.00 CHF
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Changer de vue
1 G
74.20 CHF
5 G
186.00 CHF
10 G
315.00 CHF
About This Item
Formule empirique (notation de Hill):
C22H24N2O8 · HCl · 0.5H2O · 0.5C2H6O
Numéro CAS:
Poids moléculaire :
512.94
Beilstein:
5702728
Numéro MDL:
Code UNSPSC :
12352207
Nomenclature NACRES :
NA.22
Produits recommandés
Nom du produit
Doxycycline hyclate, Suitable for Cell Culture
Niveau de qualité
Forme
powder
Température de stockage
2-8°C
Chaîne SMILES
Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58
InChI
1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10?,14?,15-,17-,22-;;;;/m00..../s1
Clé InChI
HALQELOKLVRWRI-ZVACAFRPSA-N
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Description générale
General description
Chemical structure: tetracycline
Doxycycline hyclate belongs to the second generation of tetracycline antibiotics family. Doxycycline hyclate shows minimal side effects upon usage. It is effective for the treatment of recurrent aphthous stomatitis (RAS) and promotes speedy recovery.
Chemical structure: tetracycline
Doxycycline hyclate belongs to the second generation of tetracycline antibiotics family. Doxycycline hyclate shows minimal side effects upon usage. It is effective for the treatment of recurrent aphthous stomatitis (RAS) and promotes speedy recovery.
Application
Doxycycline hyclate has been used for the induction of glioma cells and human embryonic kidney 293T cells (HEK293T).
Doxycycline hyclate is a synthetic oxytetracycline derivative. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is a broad spectrum inhibitor used to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase in studies on wound healing and tissue remodeling.
Doxycycline hyclate is a synthetic oxytetracycline derivative. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is a broad spectrum inhibitor used to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase in studies on wound healing and tissue remodeling.
Actions biochimiques/physiologiques
Mode d'action : L'hyclate de doxycycline inhibe la réponse inflammatoire à l'agent de la maladie de Lyme, le spirochète Borrelia burgdorferi.
Spectre d'activité : Inhibiteur à large spectre des métalloprotéinases matricielles in vivo.
Spectre d'activité : Inhibiteur à large spectre des métalloprotéinases matricielles in vivo.
Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi. It is a broad spectrum inhibitor of matrix metalloproteinases in vivo.
Conditionnement
1, 5, 10 g in glass bottle
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
Organes cibles
Respiratory system
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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What temperature should a solution be stored?
1 answer-
Helpful?
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Is this product suitable for in-vivo use (added to drinking water)? Also what is the difference between this product (D5207) and D9891? thank you
1 answer-
This product is intended for research use only. It is not suitable for human or veterinary use. The material has not been tested in animal models for ingestion. The end user would need to determine suitability. The major difference between product D5207 and D9891 is the testing performed. Product D5207 is tested suitable for cell culture applications. Please see the product specification sheet below regarding testing:
https://www.sigmaaldrich.com/specification-sheets/330/944/D5207-10G.pdf
https://www.sigmaaldrich.com/specification-sheets/323/301/D9891-25G.pdfHelpful?
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Hello. I have a question regarding the ref D5207 Doxycycline hyclate. I would like to know how I can resuspend the powder (DMSO, H2O, etc...). And at which concentration. Is that 10 mg/ml ok ? Thank you.
1 answer-
This product is soluble in water (50 mg/mL), and in DMSO (10 mg/mL) yielding a clear solution. Mild warming may be required to fully dissolve the material.
Please see the product data sheet for more information:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/402/297/d5207dat.pdfHelpful?
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