C7291

Clomipramine hydrochloride

≥98% (HPLC), powder

• Synonyme(s) : 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, Anafranil hydrochloride
• Formule empirique (notation de Hill): C₁₉H₂₃ClN₂ · HCl
• Numéro CAS: 17321-77-6
• Poids moléculaire : 351.31
• Numéro CE : 241-344-3
• Numéro MDL: MFCD00069234
• Code UNSPSC : 12352116
• ID de substance PubChem : 24278087
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to off-white
• Solubilité: H₂O: 25 mg/mL; 0.1 M HCl: soluble
• Auteur: Novartis
• Chaîne SMILES: Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13
• InChI: 1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H
• Clé InChI: WIMWMKZEIBHDTH-UHFFFAOYSA-N
• Informations sur le gène: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

Description

Description générale

Clomipramine hydrochloride is an antiobsessional drug.[1] It has anticholinergic activity in vitro and in vivo. Clomipramine is used to treat obsessive compulsive disorder and panic disorder.[2]

Application

Clomipramine hydrochloride has been used to manipulate serotonin (5-HT) mechanisms.[3] It has also been used to study its role on bone mass.[4]

Clomipramine hydrochloride has been used:

• to study its effect on human serum albumin using UV-visible, fluorescence and circular dichroism (CD) techniques[5]
• to block itchy E3 ubiquitin protein ligase (ITCH) ubiquitin transthiolation[6]
• as a serotonin reuptake inhibitor[7]
• as a homologous to E6AP C terminus (HECT) E3 ligase inhibitor[8]

Actions biochimiques/physiologiques

Clomipramine hydrochloride (CLP) is a amphiphilic drug,[5] with two benzene rings in its structure.[9] It exhibits anti-depressant property by restoring the equilibrium of certain natural materials in the human being. CLP acts as a potential therapeutic for obsessive compulsive disorder.[5]

Tricyclic antidepressant; inhibits serotonin and norepinephrine transporters.

Caractéristiques et avantages

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H302,H336,H370,H410
• Conseils de prudence: P260 - P264 - P271 - P273 - P301 + P312 - P308 + P311
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3
• Organes cibles: Central nervous system, Central nervous system,Cardiovascular
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves