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Merck
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Principaux documents

B9806

Sigma-Aldrich

Heparin−biotin sodium salt

≥97%

Synonyme(s) :

Heparin-Biotin Conjugate

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About This Item

Numéro MDL:
MFCD03457057
Code UNSPSC :
12352201
eCl@ss :
34058011
Nomenclature NACRES :
NA.25

612.00 CHF

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Devis pour commande en gros

Conjugué

biotin conjugate

Niveau de qualité

200

Essai

≥97%

Forme

solid

Poids mol.

~15000 Da

Solubilité

H2O: soluble 1 mg/mL, clear, colorless

Température de stockage

2-8°C

Catégories apparentées

Application

Heparin-biotin is used transfection research for the development of self-assembled terplexes such as polyamidoamine dendrimer and DNA (PAMAM/DNA) heparin-biotin terplexes for targeted gene delivery with improved transfection. The terplexes may be used in immobilizing proteins such as lactoferrin and lysozyme and nucleic acids.[1][2]

Autres remarques

Biotin conjugated to heparin from porcine intestinal mucosa

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
MKCT7646
MKCT6676
MKCS7114
MKCQ8048
MKCP6851

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Xue-Qing Zhang et al.
Bioconjugate chemistry, 18(6), 2068-2076 (2007-09-13)
We report on the preparation and characterization of poly(D, L-lactide-co-glycolide) (PLGA) microparticles with surface-conjugated polyamidoamine (PAMAM) dendrimers of varying generations. The buffering capacity and zeta-potential of the PLGA PAMAM microparticles increased with increasing generation level of the PAMAM dendrimer conjugated.
S Zou et al.
Comparative biochemistry and physiology. B, Comparative biochemistry, 103(4), 889-895 (1992-12-01)
1. Binding of biotin-heparin to immobilized lactoferrin and lysozyme was optimum at pH 6.0, 100 mM NaCl. Complex interactions between NaCl and CaCl2 concentrations were observed for heparin binding to both proteins. 2. The metal ions Cu2+, Zn2+, Fe2+ and
Nan Liu et al.
Die Pharmazie, 67(2), 174-181 (2012-04-20)
The efficiency and safety of gene delivery vectors were important factors for gene therapy. To enhance gene transfection efficiency and to incorporate biocompatible components to the polyamidoamine (PAMAM) dendrimer mediated gene delivery systems, human serum albumin (HSA) was introduced to
Kelly M Kitchens et al.
Advanced drug delivery reviews, 57(15), 2163-2176 (2005-11-18)
This article summarizes our efforts to evaluate the potential of poly (amidoamine) (PAMAM) dendrimers as carriers for oral drug delivery. Specifically, the permeability of a series of cationic PAMAM-NH2 (G0-G4) dendrimers across Caco-2 cell monolayers was evaluated as a function
Qiao Zhang et al.
Bioconjugate chemistry, 21(11), 2086-2092 (2010-10-12)
To improve transfection efficiency and to incorporate target ligands to the gene delivery systems, heparin and heparin-biotin were introduced to complexes of polyamidoamine dendrimer and DNA (PAMAM/DNA) via electrostatic interactions to form self-assembled PAMAM/DNA/heparin and PAMAM/DNA/heparin-biotin terplexes, respectively. The self-assembled
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Questions

  1. Hello, is this product (B9806) a mixture of heparin lengths? How accurate is your estimation that it is 15000 daltons in size? How is this product made? Synthetically or by purification from an animal sample?

    1 answer

    1. The quality specification for product B9806 is that the molecular weight is approximately 15000 Daltons. This is only an approximation and no specific screening has been performed for other chain lengths. The source of the heparin is from porcine intestinal mucosa. The biotinylation method is considered proprietary.

      The following reference provides information on the biotinylation of heparin:
      Stearns, N., et al., Synthesis and Characterization of Highly Sensitive Heparin Probes for Detection of Heparin-Binding Proteins. Analytical Biochemistry, 247, 348 (1997).

      Helpful?

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