46985

Fluorescein-5-thiosemicarbazide

suitable for fluorescence, ~80% (HPCE)

• Formule empirique (notation de Hill): C₂₁H₁₅N₃O₅S
• Numéro CAS: 76863-28-0
• Poids moléculaire : 421.43
• Numéro MDL: MFCD00155658
• Code UNSPSC : 12352125
• ID de substance PubChem : 329757284
• Nomenclature NACRES : NA.32

Propriétés

• Essai: ~80% (HPCE)
• Niveau de qualité: 100
• Forme: solid
• Solubilité: DMF: soluble; H₂O: soluble
• Fluorescence: λ_ex 492 nm; λ_em 516 nm in 0.1 M Tris pH 9.0
• Adéquation: suitable for fluorescence
• Température de stockage: −20°C
• Chaîne SMILES: NNC(=S)Nc1ccc(c(c1)C(O)=O)C2=C3C=CC(=O)C=C3Oc4cc(O)ccc24
• InChI: 1S/C21H15N3O5S/c22-24-21(30)23-10-1-4-13(16(7-10)20(27)28)19-14-5-2-11(25)8-17(14)29-18-9-12(26)3-6-15(18)19/h1-9,25H,22H2,(H,27,28)(H2,23,24,30)
• Clé InChI: MEUCHQDLZYLNQY-UHFFFAOYSA-N

Description

Description générale

Fluorescein-5-thiosemicarbazide, also known as FTC, is a fluorescent probe.[1] The FTSC fluorescent spectra is like FITC, a preferred fluorescent tag for proteomics. The fluorescence spectral properties of FTSC-labeled vesicles obtained by reductive amination are fully compatible with the argon laser of fluorescent instruments.[2]

Application

Fluorescein-5-thiosemicarbazide can be used as a fluorescent labeling reagent to label:

• Cell-surface functional groups (glycophorins) in the study of the effect of deoxygenation in the red blood cell membrane.[3]
• Saccharides applicable in polysaccharide imaging in live cells.[4]
• Chondroitin sulfate nanogels applicable in cell-specific drug delivery applications.[5]

Caractéristiques et avantages

Fluorescein-5-thiosemicarbazide has the following benefits -

• It displays strong fluorescence property.[2]
• Shows an intrinsic reactivity of the thiosemicarbazide group towards the aldehyde group.[2]

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)