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M3157

Supelco

Minaprine dihydrochloride

analytical standard

Synonyme(s) :

N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine

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About This Item

Formule empirique (notation de Hill):
C17H22N4O · 2HCl
Numéro CAS:
25905-77-5
Poids moléculaire :
371.30
Numéro CE :
247-329-8
Numéro MDL:
MFCD00083410
Code UNSPSC :
41116107
ID de substance PubChem :
329817964
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

200

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

forensics and toxicology
pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

Cl.Cl.Cc1cc(nnc1NCCN2CCOCC2)-c3ccccc3

InChI

1S/C17H22N4O.2ClH/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21;;/h2-6,13H,7-12H2,1H3,(H,18,20);2*1H

Clé InChI

GNUCGROXDZMCJI-UHFFFAOYSA-N

Informations sur le gène

human ... ACHE(43) , CHRM1(1128) , DRD2(1813) , HTR2B(3357) , HTR2C(3358) , MAOA(4128) , SLC6A4(6532)
rat ... Ache(83817) , Camk2a(25400) , Prkca(24680)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Actions biochimiques/physiologiques

Antidepressant

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

C A Lorenzini et al.
Pharmacology, biochemistry, and behavior, 45(2), 481-485 (1993-06-01)
The nootropic activity of 3-(2-morpholino-ethylamino)-4-methyl-6-phenyl-pyridazine dihydrochloride (minaprine) has been investigated in intact male, adult Long Evans rats by means of an active avoidance paradigm. In the light-dark box apparatus, the rat had to learn the active avoidance response of going
A Imperato et al.
Neuroscience letters, 166(1), 69-72 (1994-01-17)
Subchronic (5 mg/kg daily for 9 consecutive days) but not acute minaprine treatment enhanced in vivo dopamine release in the limbic part of the striatum of rats as revealed by intracerebral microdialysis. Moreover, the same subchronic treatment with minaprine reduced
S Cabib et al.
Psychopharmacology, 121(1), 73-80 (1995-09-01)
Different types of clinically effective antidepressants prevent the behavioral effects of experimental stress, and some of these treatments affect mesolimbic dopamine (DA) functioning. Animal studies have demonstrated that repeated psychostimulant administration and repeated or chronic stressful experiences also affect mesolimbic
J G Edwards et al.
British journal of clinical pharmacology, 42(4), 491-498 (1996-10-01)
1. A double-blind, multicentre study comparing the efficacy and safety of minaprine and amitriptyline in patients with major depression was carried out. Five hundred and thirty-one patients were randomly assigned to treatment with either minaprine 100 mg, 200 mg or
T R Norman et al.
The Australian and New Zealand journal of psychiatry, 26(1), 73-81 (1992-03-01)
A review of the clinical efficacy of four structurally distinct antidepressant drugs is presented. Their antidepressant activity can be rationalised within current pharmacological hypotheses of drug action, despite markedly different effects on "in vitro" testing. Fluoxetine, a specific serotonin re-uptake
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