475895

Monensin, Sodium Salt, High Purity

Polyether antibiotic that functions as a Na⁺ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane.

• Synonyme(s) : Monensin, Sodium Salt, High Purity
• Formule empirique (notation de Hill): C₃₆H₆₁O₁₁ · Na
• Numéro CAS: 22373-78-0
• Poids moléculaire : 692.85
• Numéro MDL: MFCD00077826
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (by Assay)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: off-white to beige
• Solubilité: chloroform: soluble; ethanol: soluble; methanol: soluble
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35+,36-;/m0./s1
• Clé InChI: XOIQMTLWECTKJL-FBZUZRIGSA-M

Description

Description générale

Polyether antibiotic that functions as a Na⁺ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane. Blocks glycoprotein secretion. Inhibits the ability of HDL to decrease cellular cholesterol esterification. Also reported to induce catecholamine secretion from adrenal chromaffin cells.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Functions as a Na+ ionophore

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Highly Toxic (H)

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C. Unstable in acidic solutions.

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Inabayashi, M., et al. 1995. Biochemistry34, 3455.
Mendez, A.J. 1995. J. Biol. Chem.270, 5891.
Sakuragawa, N., et al. 1994. Biochim. Biophys. Acta1213, 193.
Griffin, T., et al. 1993. J. Natl. Cancer Inst.85, 292.
Rushfeldt, C., and Smedsrtod, B. 1993. Cancer Res.53, 658.
Hoya, A., and Venosa, R.A. 1992. Biochem. Biophys. Acta1104, 123.
Kok, J.W. 1992. J. Cell. Sci.103, 1139.
Takemura, H., and Ohshika, H. 1992. Biochem. Pharmacol.44, 1395.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H300,H319,H373,H411
• Conseils de prudence: P260 - P264 - P273 - P301 + P310 - P305 + P351 + P338 - P314
• Classification des risques: Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - STOT RE 2
• Organes cibles: Heart,muscle
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable