- [Lanthanides induce neurotransmitter release from the vesicular pool in rat brain synaptosomes].
[Lanthanides induce neurotransmitter release from the vesicular pool in rat brain synaptosomes].
Biofizika (2005-12-20)
L P Lopatina, T V Vasim, S V Fedorovich, S V Konev
PMID16358793
ZUSAMMENFASSUNG
The influence of lanthanoids on exocytosis was investigated. It was shown that gadolinium increases the spontaneous release of the glutamate nonmetabolizing analogue [3H]D-aspartate. It was established using the fluorescent dye acridine orange that gadolinium and lanthanum induce exocytosis. The effect was dose-dependent and was maximum at 300 microM Gd3+. The exocytosis induced by gadolinium was calcium-independent. It is suggested that lanthanides induce a vesicular release of neurotransmitters by the mechanisms common for all polyvalent cations.