Direkt zum Inhalt
Merck

Effects of phenylalaninol on centrally induced gastric acid secretion.

Chemical & pharmaceutical bulletin (1992-11-01)
H Hashizume, T Miyamae, T Morikawa, M Hagiwara
ZUSAMMENFASSUNG

The effects of phenylalaninol (D-isomer) on gastric acid secretion and gastric ulcer were studied in rats. The compound reduced the gastric acid secretion stimulated by intracisternal thyrotropin releasing hormone and intravenous 2-deoxy-D-glucose, but not that stimulated by subcutaneous carbachol or histamine. Phenylalaninol prevented stress- and indomethacin-induced gastric ulcers. We conclude that phenylalaninol inhibits ulcer formation mainly by central inhibition of gastric acid secretion.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
L-Phenylalaninol, 98%, optical purity ee: 99% (HPLC)