U6881

U-73343

• Synonym(e): 1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-2,5-pyrrolidinedione
• Empirische Formel (Hill-System): C₂₉H₄₂N₂O₃
• CAS-Nummer: 142878-12-4
• Molekulargewicht: 466.66
• MDL-Nummer: MFCD00211221
• UNSPSC-Code: 41106300
• PubChem Substanz-ID: 24900662
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white
• Löslichkeit: DMSO: soluble
• SMILES String: [H][C@]12CC[C@]3(C)[C@H](CC[C@@]3([H])[C@]1([H])CCc4cc(OC)ccc24)NCCCCCCN5C(=O)CCC5=O
• InChI: 1S/C29H42N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,19,23-26,30H,3-7,9,11-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1
• InChIKey: CJHWFIUASFBCKN-ZRJUGLEFSA-N

Beschreibung

Allgemeine Beschreibung

U-73343 is used to assess the involvement of G protein-coupled 1-phosphatidylinositol-phosphodiesterase or phospholipase C in receptor-mediated cell activation. It functions downstream of phospholipase C to block receptor-mediated phospholipase D activation.[1]

Anwendung

U-73343 has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na⁺ channel (ENaC) function in gerbil Reissner′s membranes (RMs)[2]. U-73343 has also been used as a negative control for PLC inhibition in mechanically stimulated (MS) and its neighboring (NB) cells[3].

U-73343 has been used in measuring the fluorescence of intracellular Ca²⁺.[4]

Biochem./physiol. Wirkung

Inactive analog of U73122; used as a negative control.

Angaben zur Herstellung

U-73343 is soluble in chloroform at 10 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in ethanol (0.93 mg/ml) and DMSO (2.3 mg/ml), but is insoluble in water.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves