Currently, there are no salt forms of this compound available.
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T144
(±)-Thalidomid
≥98%, powder
Synonym(e):
2-(2,6-Dioxo-3-piperidinyl)-1H-isoindol-1,3(2H)-dion
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100 MG
CHF 121.00
1 G
CHF 830.00
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100 MG
CHF 121.00
1 G
CHF 830.00
About This Item
Empirische Formel (Hill-System):
C13H10N2O4
CAS-Nummer:
Molekulargewicht:
258.23
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352111
eCl@ss:
39180303
PubChem Substanz-ID:
NACRES:
NA.77
Empfohlene Produkte
ligand
thalidomide
Assay
≥98%
Form
powder
Eignung der Reaktion
reagent type: ligand
Farbe
white
Löslichkeit
DMSO: 20 mg/mL, clear
Ersteller
Celgene
SMILES String
O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1
InChI
1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
InChIKey
UEJJHQNACJXSKW-UHFFFAOYSA-N
Angaben zum Gen
human ... CRBN(51185) , CUL4A(8451) , DDB1(1642) , LITAF(9516) , RBX1(9978) , TNF(7124)
mouse ... Nos2(18126)
rat ... Nos1(24598)
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Verwandte Kategorien
Anwendung
Thalidomide has been used to study its neuropathological effects in mouse models of Alzheimer′s disease (AD). This study reported that long term administration of thalidomide causes beta-secretase inhibition and subsequently alleviates amyloid-like pathology[1]. Furthermore, thalidomide has also been used to evaluate its teratogenic functions. Thalidomide was found to affect endodermal differentiation and neural development in differentiating human embryonic and induced pluripotent stem cells[2].
Biochem./physiol. Wirkung
(±)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). It also functions as an inhibitor of angiogenesis, an immunosuppressive agent, a sedative and a teratogen. Furthermore, thalidomide is known to exhibit antitumor functions in refractory multiple myeloma[3].
Leistungsmerkmale und Vorteile
This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Angaben zur Herstellung
Thalidomide is soluble in DMSO at a concentration that is more than 20 mg/ml. It is insoluble in water and ethanol.
Anwendung
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Produkt-Nr.
Beschreibung
Preisangaben
Signalwort
Danger
H-Sätze
Gefahreneinstufungen
Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
Lagerklassenschlüssel
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Persönliche Schutzausrüstung
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Kunden haben sich ebenfalls angesehen
Yoav Mayshar et al.
Journal of cellular and molecular medicine, 15(6), 1393-1401 (2010-06-22)
Teratogens are substances that may cause defects in normal embryonic development while not necessarily being toxic in adults. Identification of possible teratogenic compounds has been historically beset by the species-specific nature of the teratogen response. To examine teratogenic effects on
Marzia Lazzerini et al.
JAMA, 310(20), 2164-2173 (2013-11-28)
Pediatric-onset Crohn disease is more aggressive than adult-onset disease, has high rates of resistance to existing drugs, and can lead to permanent impairments. Few trials have evaluated new drugs for refractory Crohn disease in children. To determine whether thalidomide is
S Singhal et al.
The New England journal of medicine, 341(21), 1565-1571 (1999-11-24)
Patients with myeloma who relapse after high-dose chemotherapy have few therapeutic options. Since increased bone marrow vascularity imparts a poor prognosis in myeloma, we evaluated the efficacy of thalidomide, which has antiangiogenic properties, in patients with refractory disease. Eighty-four previously
Karin Lauschke et al.
Archives of toxicology, 95(5), 1659-1670 (2021-03-05)
To test large numbers of chemicals for developmental toxicity, rapid in vitro tests with standardized readouts for automated data acquisition are needed. However, the most widely used assay, the embryonic stem cell test, relies on the counting of beating embryoid
Tomomi Noguchi et al.
Bioorganic & medicinal chemistry letters, 15(24), 5509-5513 (2005-09-27)
5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (5HPP-33: 10), which was obtained during our previous structural development studies on thalidomide, was revealed to possess potent anti-angiogenic activity in a human umbilical vein endothelial cell (HUVEC) assay. Thalidomide (1) and its metabolite, 5-hydroxythalidomide (5-HT: 2), which possesses
Artikel
Effective in key synthesis reactions like Knoevenagel condensation, thalidomide synthesis, and Suzuki coupling for sustainable chemical transformations.
Chromatograms
application for HPLCapplication for HPLC-
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