SRP8052

CD279 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• Synonym(e): Hepatitis A virus cellular receptor 2, PD-1, Programmed cell death protein 1
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in CHO cells
• Assay: ≥98% (SDS-PAGE)
• Form: lyophilized
• Mol-Gew.: monomer 46 kDa by calculation
• Verpackung: pkg of 100 μg
• Verunreinigungen: <0.06 EU/μg endotoxin, tested
• UniProt-Hinterlegungsnummer: Q15116
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... PDCD1(5133)

Beschreibung

Allgemeine Beschreibung

Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-γ. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

Physikalische Form

Lyophilized from 0.2 μm-filtered solution in PBS.

Rekonstituierung

Reconstitute at 100 μg/mL in sterile PBS.

Sonstige Hinweise

The extracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc region of human IgG1.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable