SRP2163

Estrogen Receptor human

recombinant, expressed in insect cells, ≥80% (SDS-PAGE)

• Synonym(e): DKFZp686N23123, ER, ESR, ESRA, Era, NR3A1
• UNSPSC-Code: 12352200
• NACRES: NA.26

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in insect cells
• Assay: ≥80% (SDS-PAGE)
• Form: frozen liquid
• Mol-Gew.: ~68 kDa
• Verpackung: pkg of 4 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Konzentration: 200 μg/mL
• Farbe: colorless to clear
• NCBI-Hinterlegungsnummer: NM_000125
• UniProt-Hinterlegungsnummer: P03372
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... ESR1(2099)

Beschreibung

Allgemeine Beschreibung

The gene ESR1 (estrogen receptor-alpha) encodes a member of the superfamily of nuclear hormone receptors that are essential for the functioning of female reproductive system. The gene is mapped to human chromosome 6q25.

Biochem./physiol. Wirkung

Several members of the nuclear receptor family are directly associated with human malignancies including breast cancer, prostate cancer and leukemia. The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; estrogen receptor-alpha (ER alpha) in breast cancer, androgen receptor (AR) in prostate cancer, and retinoic acid receptor alpha (RAR alpha) in acute promyelocytic leukemia. Estrogen receptors (ER) are members of the superfamily of nuclear hormone receptors (2, 3) whose activity is required for the normal function of the female reproductive system. Two isoforms of estrogen receptor (ER α and ER β) have been described. They function as ligand-dependent transcriptional activators. The biological functions downstream of ER result from altered expression of direct transcriptional targets as well as secondary effects mediated by biological activities of direct targets. In the mammary gland, estrogen receptors regulate normal epithelial cell development and differentiation through their well-documented effects on transcription. Estrogens have long been known to have mitogenic functions in breast cancer cell lines and in breast tumors. Selective estrogen receptor modulatory compounds (SERMs), which bind directly to ER, can block the growth stimulatory function of estrogens.

Physikalische Form

Clear and colorless frozen liquid solution

Angaben zur Herstellung

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable