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Ursprungszeugnis (CoO)/Analysenzertifikate (CoA)

SRP0437

PDE7B active rat

Name: PDE7B active rat
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥30% (SDS-PAGE)

Synonym(e):

phosphodiesterase 7B

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About This Item

UNSPSC-Code:

12352200

NACRES:

NA.32

Biologische Quelle

rat

Rekombinant

expressed in baculovirus infected Sf9 cells

Assay

≥30% (SDS-PAGE)

Form

aqueous solution

Mol-Gew.

65 kDa

Verpackung

pkg of 10 μg

NCBI-Hinterlegungsnummer

NM_031080

UniProt-Hinterlegungsnummer

Q8VIE4

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

rat ... PDE7B(140929)

Allgemeine Beschreibung

Rat PDE7B (GenBank Accession No. NM_080894) amino acids 108-446 (end) with N-terminal GST-tag, MW=65 kDa, expressed in a Baculovirus-infected Sf9 cell expression system.

Anwendung

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia.

Lingzhi Zhang et al.

Proceedings of the National Academy of Sciences of the United States of America, 105(49), 19532-19537 (2008-11-27)

Cyclic nucleotide phosphodiesterase (PDE) isoforms can influence disease pathogenesis and be novel therapeutic targets. Because lower cAMP levels may contribute to the decreased apoptosis that occurs in chronic lymphocytic leukemia (CLL), we assessed the expression levels of PDE isoforms in

Neuronal expression of cAMP-specific phosphodiesterase 7B mRNA in the rat brain.

E Reyes-Irisarri et al.

Neuroscience, 132(4), 1173-1185 (2005-04-29)

cAMP plays an important role as second messenger molecule controlling multiple cellular processes in the brain. cAMP levels depend critically on the phosphodiesterases (PDE) activity, enzymes responsible for the clearance of intracellular cAMP. We have examined the regional distribution and

Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase.

C Gardner et al.

Biochemical and biophysical research communications, 272(1), 186-192 (2000-06-29)

We have identified and characterised a novel member of the PDE7 family of cyclic nucleotide phosphodiesterases (PDE), which we have designated PDE7B. Mouse and human full-length cDNAs were isolated encoding a protein of 446 and 450 amino acids, respectively. The

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