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SRP0328

PADI-3 human

Name: PADI-3 human
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥60% (SDS-PAGE)

Synonym(e):

Peptidyl arginine deiminase, type III

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About This Item

UNSPSC-Code:

12352200

NACRES:

NA.32

Biologische Quelle

human

Rekombinant

expressed in baculovirus infected Sf9 cells

Assay

≥60% (SDS-PAGE)

Form

aqueous solution

Mol-Gew.

75 kDa

Verpackung

pkg of 10 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Konzentration

0.25 mg/mL

NCBI-Hinterlegungsnummer

NM_016233

UniProt-Hinterlegungsnummer

Q9ULW8

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... PADI3(51702)

Allgemeine Beschreibung

Human PADI-3, also known as Peptidyl arginine deiminase, type III, (GenBank Accession No. NM_016233), amino acids 1-664 (end) with C-terminal FLAG-tag, MW= 75 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Anwendung

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes.

Sijun Dong et al.

The Biochemical journal, 397(3), 449-459 (2006-05-05)

Human peptidylarginine deiminase type III gene (PADI3) encodes a crucial post-translational modification enzyme that converts protein-bound arginine residues into citrulline residues. Its expression is restricted to a few cell types, including keratinocytes in the granular layer of the epidermis and

Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin.

T Kanno et al.

The Journal of investigative dermatology, 115(5), 813-823 (2000-11-09)

Peptidylarginine deiminase catalyzes the post-translational modification of proteins through the conversion of arginine to citrulline in the presence of calcium ions. In rodents, peptidylarginine deiminase has been classified into four isoforms, types I, II, III, and IV, which are distinct

Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin.

Rachida Nachat et al.

The Journal of investigative dermatology, 124(2), 384-393 (2005-01-29)

Post-translational conversion of arginine to citrulline residues is catalyzed by peptidylarginine deiminases (PAD). Although the existence of five isoforms of PAD has been reported in rodents and humans, their tissue distribution, substrate specificity, and physiological function have yet to be

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