SML4031

BAX Dimer Modulator 19, BDM19

≥98% (HPLC)

• Synonym(e): BDM-19, (E)-4-(6-Iodo-2-(3-methylstyryl)-4-oxoquinazolin-3(4H)-yl)benzoic acid, 4-[6-Iodo-2-[2-(3-methylphenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]benzoic acid, BDM 19, BDM19
• Empirische Formel (Hill-System): C₂₄H₁₇IN₂O₃
• CAS-Nummer: 500273-31-4
• Molekulargewicht: 508.31
• MDL-Nummer: MFCD03302943
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear (Warmed)
• Lagertemp.: 2-8°C
• SMILES String: IC1=CC=C2C(C(N(C(/C=C/C3=CC(C)=CC=C3)=N2)C4=CC=C(C=C4)C(O)=O)=O)=C1

Beschreibung

Biochem./physiol. Wirkung

Potent and selective cytosolic BAX dimer modulator that effectively induces apoptosis in cancer cells by selectively modulating inactive BAX.

BDM19, a potent BAX dimer modulator with a Kd of 560 nM, selectively binds to the N-terminal trigger site of inactive BAX, thereby inhibiting its dimerization with an IC50 of 5 μM. By stabilizing the inactive conformation of BAX, BDM-19 allosterically activates it, targeting cells containing cytosolic inactive BAX monomers and dimers. This leads to a dose-dependent translocation of BAX to mitochondria, subsequent cytochrome c release, and induction of apoptosis.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable