SML2940

ML417

≥98% (HPLC)

• Synonym(e): (1H-Indol-2-yl)(4-(2-(4-methoxyphenoxy)ethyl)piperazin-1-yl)methanone, Methanone, 1H-indol-2-yl[4-[2-(4-methoxyphenoxy)ethyl]-1-piperazinyl]-
• Empirische Formel (Hill-System): C₂₂H₂₅N₃O₃
• CAS-Nummer: 1386162-69-1
• Molekulargewicht: 379.45
• MDL-Nummer: MFCD32693923
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: N2(CCN(CC2)C(=O)c3[nH]c4c(c3)cccc4)CCOc1ccc(cc1)OC
• InChIKey: HAZPAMUWUHDPDA-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

ML417 is a blood-brain barrier permeable, potent and highly selective agonist of D3 dopamine receptor (D3R) with very limited cross-reactivity at other GPCRs. ML417 potently induces G-protein activation, D3R-mediated b-arrestin translocation and pERK phosphorylation. It does not activate other dopamine receptors. ML417 protect D3R-expressing dopaminergic neurons from 6-OHDA induced cell death.

blood-brain barrier permeable, potent and highly selective agonist of D3 dopamine receptor (D3R)

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable