SML1392

FDI-6

≥98% (HPLC)

• Synonym(e): 3-Amino-N-(4-fluorophenyl)-6-(2-thienyl)-4-(trifluoromethyl)-thieno[2,3-b]pyridine-2-carboxamide, 3-Amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide, NCGC00099374
• Empirische Formel (Hill-System): C₁₉H₁₁F₄N₃OS₂
• CAS-Nummer: 313380-27-7
• Molekulargewicht: 437.43
• MDL-Nummer: MFCD01416826
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825840
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder (flocculent)
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: NC1=C(C(NC2=CC=C(F)C=C2)=O)SC3=C1C(C(F)(F)F)=CC(C4=CC=CS4)=N3
• InChI: 1S/C19H11F4N3OS2/c20-9-3-5-10(6-4-9)25-17(27)16-15(24)14-11(19(21,22)23)8-12(26-18(14)29-16)13-2-1-7-28-13/h1-8H,24H2,(H,25,27)
• InChIKey: ZATJMMZPGVDUOM-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

FDI-6 is a potent and specific inhibitor of FOXM1 that blocks DNA binding. FDI-6 binds to FOXM1 protein and specifically downregulates FOXM1-activated genes.

FDI-6 is a potent and specific inhibitor of FOXM1.

Forkhead domain inhibitor-6 (FDI-6) is used to treat anaemia patients because of diminished red blood production.[1] In Hep-2 cells, FDI-6 can stimulate cell death and also helps to prevent cell proliferation, invasion and migration.[2]

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable