SML0431

PQ1 succinate

≥98% (HPLC)

• Synonym(e): N1-[6-Methoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]-1,3-propanediamine butanedioic acid salt, PQ1 succinic acid salt
• Empirische Formel (Hill-System): C₂₅H₂₈F₃N₃O₆
• CAS-Nummer: 955995-51-4
• Molekulargewicht: 523.50
• MDL-Nummer: MFCD22666397
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329824715
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to brown
• Löslichkeit: DMSO: 15 mg/mL (clear solution)
• Lagertemp.: 2-8°C
• SMILES String: OC(=O)CCC(O)=O.COc1cc(NCCCN)c2nccc(C)c2c1Oc3cccc(c3)C(F)(F)F
• InChI: 1S/C21H22F3N3O2.C4H6O4/c1-13-7-10-27-19-16(26-9-4-8-25)12-17(28-2)20(18(13)19)29-15-6-3-5-14(11-15)21(22,23)24;5-3(6)1-2-4(7)8/h3,5-7,10-12,26H,4,8-9,25H2,1-2H3;1-2H2,(H,5,6)(H,7,8)
• InChIKey: XFEIMRMBZQODRY-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

PQ1 binds tightly to connexin 43 and activates intracellular gap junctions. Treatment of the breast cancer cell line T47D with 200 nM PQ1 induces a 30% increase in gap junctional intercellularcommunication (GJIC) and a 90% decrease in cell growth, with no effect on normal breast epithelial cells.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable