SML0269

Nitisinone

≥95% (HPLC)

• Synonym(e): 2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione, NTBC, Nitisone, SC 0735
• Empirische Formel (Hill-System): C₁₄H₁₀F₃NO₅
• CAS-Nummer: 104206-65-7
• Molekulargewicht: 329.23
• MDL-Nummer: MFCD01752192
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825277
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: powder
• Farbe: white to brown
• Löslichkeit: DMSO: ≥5 mg/mL
• Lagertemp.: −20°C
• SMILES String: [O-][N+](=O)c1cc(ccc1C(=O)C2C(=O)CCCC2=O)C(F)(F)F
• InChI: 1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
• InChIKey: OUBCNLGXQFSTLU-UHFFFAOYSA-N
• Angaben zum Gen: human ... HPD(3242)

Beschreibung

Anwendung

Nitisinone has been used:

• to induce liver injury[1]
• to treat Ixodes scapularis tick cells to inhibit the activity of hydroxyphenylpyruvate dioxygenase[2]
• in supplemented water to block the accumulation of toxic metabolites in human hepatocyte engrafted mice[3]
• to study its effect on bacterial pyomelanin production[4]

Biochem./physiol. Wirkung

Nitisinone is a competitive and reversible inhibitor of 4-Hydroxyphenylpyruvate oxidase (dioxygenase).

Nitisinone is a competitive inhibitor that reversibly inhibits 4-Hydroxyphenylpyruvate oxidase (dioxygenase). Nitisinone is used in the treatment of hereditary tyrosinemia type 1, where it blocks the degradation of tyrosine into harmful substances.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable