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SML0153

Sigma-Aldrich

Geniposid

≥98% (HPLC)

Synonym(e):

(1S,4αS,7αS)- 1-(β-D-Glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)- cyclopenta[c]pyran-4-carboxylic acid methyl ester

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About This Item

Empirische Formel (Hill-System):
C17H24O10
CAS-Nummer:
24512-63-8
Molekulargewicht:
388.37
MDL-Nummer:
MFCD16036219
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825201
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

white to beige

Löslichkeit

H2O: ≥5 mg/mL

Versandbedingung

wet ice

Lagertemp.

−20°C

SMILES String

COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]3[C@@H]1CC=C3CO

InChI

1S/C17H24O10/c1-24-15(23)9-6-25-16(11-7(4-18)2-3-8(9)11)27-17-14(22)13(21)12(20)10(5-19)26-17/h2,6,8,10-14,16-22H,3-5H2,1H3/t8-,10-,11-,12-,13+,14-,16+,17+/m1/s1

InChIKey

IBFYXTRXDNAPMM-BVTMAQQCSA-N

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Biochem./physiol. Wirkung

Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation and upregulate downstream antioxidant protein HO-1 expression through the PI3K/Akt signaling pathway, which may account for its neuroprotective and antioxidative activity. Glucagon-like peptide 1 (GLP-1) receptor may also play a critical role in geniposide induced HO-1 expression.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Gentiopicrosid ≥98% (HPLC)

Sigma-Aldrich

SMB00416

Gentiopicrosid

Loganin analytical standard

Supelco

36483

Loganin

Aucubin analytical standard

Supelco

55561

Aucubin

Berberinchlorid Hydrat technical, ≥90% (AT)

Sigma-Aldrich

14050

Berberinchlorid Hydrat

Polydatin ≥95% (HPLC)

Sigma-Aldrich

15721

Polydatin

Crocin for microscopy

Sigma-Aldrich

17304

Crocin

Jian Li et al.
PloS one, 7(9), e45811-e45811 (2012-10-11)
Refined Qing-Kai-Ling (QKL), a modified Chinese medicine, consists of three main ingredients (Baicalin, Jasminoidin and Desoxycholic acid), plays a synergistic effect on the treatment of the acute stage of ischemic stroke. However, the rules of the combination and synergism are
Yan-Jing Li et al.
Rapid communications in mass spectrometry : RCM, 26(11), 1377-1384 (2012-05-05)
The Direct Analysis in Real Time (DART) ionization source coupled with a quadrupole time-of-flight tandem mass spectrometry (Q-TOF MS/MS) system has the capability to desorb analytes directly from samples from complex Chinese herbal preparations without sample cleanup or chromatographic separation.
Jianhui Liu et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(7), 1093-1097 (2012-07-24)
β-Cell apoptosis is considered to be a major cause of loss of β cells in diabetes. Geniposide could prevent oxidative stress-induced neuron apoptosis, and improved glucose stimulated insulin secretion by activating glucagon-like peptide 1 receptor (GLP-1R) in INS-1 cells. Here
K Hiramatsu et al.
Alimentary pharmacology & therapeutics, 36(6), 575-586 (2012-07-24)
Idiopathic mesenteric phlebosclerosis (IMP) is a rare disease, characterised by thickening of the wall of the right hemicolon with calcification of mesenteric veins. However, the aetiology remains unknown. To investigate the possible association of herbal medicines with IMP. The clinical
Min Zhou et al.
Fitoterapia, 83(8), 1558-1561 (2012-09-15)
Geniposide was prepared on a large-scale using a selective two-phase liquid-liquid extraction. The aqueous residue from the fruit of Gardenia jasminoides Ellis was treated with sodium carbonate and extracted with n-butanol several times. The n-butanol extracts were treated with activated
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