SAB6010057

Anti-phospho-ERN1 (S724) antibody, clone 1F12, Rabbit Monoclonal

recombinant, expressed in HEK293F cells

• Synonym(e): Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, hIRE1p, Ire1-alpha, IRE1a, Serine/threonine-protein kinase, Endoribonuclease, ERN1
• UNSPSC-Code: 12352203

Eigenschaften

• Rekombinant: expressed in HEK 293 F cells
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörper-Produkttyp: primary antibodies
• Klon: 1F12, recombinant monoclonal
• Form: liquid
• Mol-Gew.: 150 kDa
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: human
• Konzentration: 0.6mg/ml
• Methode(n): ELISA: 2000:10000; flow cytometry: 1:50-1:200; immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200
• Isotyp: IgG
• UniProt-Hinterlegungsnummer: O75460
• Versandbedingung: wet ice
• Lagertemp.: -10 to -25°C
• Posttranslationale Modifikation Target: phosphorylation (pSer724)

Beschreibung

Allgemeine Beschreibung

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed:9637683, PubMed:11175748, PubMed:12637535). The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis (PubMed:24508390).

Immunogen

A synthesized peptide derived from human Phospho-ERN1 (S724)

Sequenz

GRH-pS-FSR

Physikalische Form

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Lagerung und Haltbarkeit

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable