Purchased this product through Sigma. There was a delay between time of purchase and time of delivery. Product arrived and tested in western blotting at dilution 1:1000 and showed multiple non specific bands on gel making data uninterpretable. Western blotting conditions: Blocking 1hr in 5% Milk TBST, Probed o/night 1:1000 in blocking buffer, after three washes secondary antibody Rabbit HRP at 1:10000 (PTG) and developed with ECL Fempto (UltraScence Femto Western Substrate)
SAB5700618
Anti-Lamin A/C antibody produced in rabbit
Anti-Lamin A/C antibody produced in rabbit
Synonym(e):
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNA, LMNC, LMNL1
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100 μL
CHF 329.00
CHF 329.00
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100 μL
CHF 329.00
About This Item
UNSPSC-Code:
12352203
NACRES:
NA.41
CHF 329.00
Check Cart for Availability
Empfohlene Produkte
Biologische Quelle
rabbit
Qualitätsniveau
Antikörperform
affinity isolated antibody
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
buffered aqueous solution
Mol-Gew.
62-74
Speziesreaktivität
human, mouse, rat
Konzentration
1.41 mg/ml
Methode(n)
immunofluorescence: 1:50-1:200
immunohistochemistry: 1:50-1:200
immunoprecipitation (IP): 1:50-1:200
western blot: 1:500-1:2000
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... LMNA(4000)
Allgemeine Beschreibung
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 403-572 of human Lamin C (NP_005563.1).
Physikalische Form
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Lagerung und Haltbarkeit
Store at -20℃. Avoid freeze / thaw cycles.
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Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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