SAB4702130

Monoclonal Anti-CD22, purified produced in mouse

• Synonym(e): SIGLEC-2, SIGLEC2
• UNSPSC-Code: 12352203

Eigenschaften

• Konjugat: unconjugated
• Qualitätsniveau: 100
• Antikörper-Produkttyp: primary antibodies
• Klon: S-HCL-1, monoclonal
• Form: buffered aqueous solution
• Speziesreaktivität: human
• Konzentration: 1 mg/ml
• Methode(n): flow cytometry: suitable
• Isotyp: IgG2bκ
• UniProt-Hinterlegungsnummer: P20273
• Lagertemp.: 2-8°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CD22(933)

Beschreibung

Allgemeine Beschreibung

CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.

Spezifität

The mouse monoclonal antibody S-HCL-1 (also known as S-HCL1) recognizes an extracellular epitope of CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes; it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes.

Immunogen

Whole hairy cell leukemia cells and membrane preparation

Physikalische Form

Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Angaben zur Herstellung

Purified by protein-A affinity chromatography.

Lagerung und Haltbarkeit

Store at 2-8°C. Do not freeze.

Sonstige Hinweise

The antibody solution should be gently mixed before use.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable