Immunoglobulin κ locus (IGK), also known as IGK@, is encoded by the gene mapped to human chromosome 2p11.2.
The antibody MEM-09 reacts with both secreted and B cell-surface human immunoglobulin, specifically reacts with kappa light chains (22.5 kDa). Material immunoprecipitated from human serum with the antibody MEM-09 consists of IgG and traces of IgM.
Immunogen
Crude thymus membrane fraction
Anwendung
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 5 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Biochem./physiol. Wirkung
Mutations in the IGK@ gene increases the risk of susceptibility to nasopharyngeal carcinoma, gastric cancer and breast cancer.
Leistungsmerkmale und Vorteile
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Physikalische Form
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Nomenclature of the human immunoglobulin kappa (IGK) genes.
Lefranc MP
Experimental and Clinical Immunogenetics, 18, 161-174 (2001)
The polymorphisms on Igkappa gene are related to susceptibility of breast cancer and gastric cancer.
Hu D
Genetic testing, 12, 575-580 (2008)
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