SAB4700323

Monoclonal Anti-HLA-G , (C-terminal) antibody produced in mouse

clone 5A6G7, purified immunoglobulin, buffered aqueous solution

• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 5A6G7, monoclonal
• Form: buffered aqueous solution
• Speziesreaktivität: human
• Konzentration: 1 mg/mL
• Methode(n): flow cytometry: suitable
• Isotyp: IgG1
• NCBI-Hinterlegungsnummer: NM_002127.5
• UniProt-Hinterlegungsnummer: P17693
• Versandbedingung: wet ice
• Lagertemp.: 2-8°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... HLA-G(3135)

Beschreibung

Allgemeine Beschreibung

Human histocompatibility leukocyte antigen–G (HLA-G) belongs to the non-classical class I HLA family. It is encoded by the gene mapped to human chromosome 6p21. Unlike other members of the human class I gene family, HLA-G is expressed specifically in extraembryonic tissues during gestation.

The antibody 5A6G7 allows to discriminate between soluble HLA-G protein yielded by shedding from membrane-bound HLA-G forms that do not contain the intron 4-encoded epitope and soluble HLA-G5/HLA-G6 produced from intron 4-retaining alternatively spliced mRNAs. HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells.

Immunogen

C-terminal amino acid sequence (22-mer) of soluble HLA-G5 and HLA-G6 proteins coupled to ovalbumin

Anwendung

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Biochem./physiol. Wirkung

Human histocompatibility leukocyte antigen-G (HLA-G) molecule facilitates the regulation of maternal tolerance to the fetus by interacting with inhibitory receptors on natural killer (NK) cells. The encoded protein is involved in the embryonic development and/or the fetal-maternal immune response. Mutations in the gene increases the risk of susceptibility to a wide range of inflammatory diseases, including asthma.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable