SAB4504640
Anti-phospho-PLK1 (pSer137) antibody produced in rabbit
affinity isolated antibody
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About This Item
UNSPSC-Code:
12352203
NACRES:
NA.41
Biologische Quelle
rabbit
Qualitätsniveau
Konjugat
unconjugated
Antikörperform
affinity isolated antibody
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
buffered aqueous solution
Mol-Gew.
antigen 68 kDa
Speziesreaktivität
mouse, human, rat
Konzentration
~1 mg/mL
Methode(n)
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
phosphorylation (pSer137)
Angaben zum Gen
human ... PLK1(5347)
Allgemeine Beschreibung
Polo-like kinase 1 (PLK1) belongs to the polo-like kinase family. PLK1 is characterized with two COOH-terminal polo box domain and N-terminal kinase domain involved in drug development. PLK1 is expressed primarily at centrosomes and at the midbody of dividing cells.
Immunogen
The antiserum was produced against synthesized peptide derived from human PLK1 around the phosphorylation site of Ser137.
Immunogen Range: 103-152
Immunogen Range: 103-152
Biochem./physiol. Wirkung
Polo-like kinase 1 (PLK1) is involved in regulation of mitosis. PLK1 plays a crucial role in centrosome-mediated microtubule events and spindle assembly. PLK1 expression is elevated in cancer tissues. Thus, it can be used as a potential prognostic marker for several cancers, including non-small-cell lung cancer, squamous-cell carcinomas of the head and neck, melanomas, colorectal cancer, oropharyngeal carcinomas, and ovarian and endometrial carcinomas. PLK1 recruited to centrosomes during S-phase by centrosomal protein FOP-related protein of 20kDa (FOR20), plays a vital role in S-phase progression. The protein also plays an essential role in central spindle formation and cytokinesis. PLK1 inhibitors might act as a potential therapeutics in cancer treatment.
Leistungsmerkmale und Vorteile
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physikalische Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Klaus Strebhardt et al.
Nature reviews. Cancer, 6(4), 321-330 (2006-03-25)
Human polo-like kinase 1 (PLK1) is essential during mitosis and in the maintenance of genomic stability. PLK1 is overexpressed in human tumours and has prognostic potential in cancer, indicating its involvement in carcinogenesis and its potential as a therapeutic target.
Birgit Spänkuch-Schmitt et al.
Journal of the National Cancer Institute, 94(24), 1863-1877 (2002-12-19)
Expression of polo-like kinase-1 (PLK1), which has several functions in mitotic progression, is elevated in a broad range of human tumors. To investigate the role of PLK1 in neoplastic proliferation, we used the technique of RNA interference. Cells from several
Takao Takahashi et al.
Cancer science, 94(2), 148-152 (2003-04-24)
PLK (polo-like kinase), the human counterpart of polo in Drosophila melanogaster and of CDC5 in Saccharomyces cerevisiae, belongs to a family of serine/threonine kinases. It is intimately involved in spindle formation and chromosome segregation during mitosis. The purpose of this
Minhong Shen et al.
Cell research, 23(11), 1284-1295 (2013-09-11)
Centrosomes are required for efficient cell cycle progression mainly by orchestrating microtubule dynamics and facilitating G1/S and G2/M transitions. However, the role of centrosomes in S-phase progression is largely unknown. Here, we report that depletion of FOR20 (FOP-related protein of
K E Mundt et al.
Biochemical and biophysical research communications, 239(2), 377-385 (1997-11-05)
The human protein kinase Plk1, a member of the polo-like kinase family, is known to function at mitosis. Here we show that the relative specific activity of Plk1 increases in mitosis, that Plk1 is specifically phosphorylated during mitosis, and that
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