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SAB4301605

Sigma-Aldrich

Anti-IL3RA

affinity isolated antibody

Synonym(e):

CD123, IL3R, IL3RAY, IL3RX, IL3RY

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous glycerol solution

Speziesreaktivität

human, mouse

Methode(n)

immunohistochemistry: 1:100-1:200
western blot: 1:500-1:2000

Hinterlegungsnummer

NP_002174

UniProt-Hinterlegungsnummer

P26951

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... IL3RA(3563)

Allgemeine Beschreibung

Interleukin 3 receptor subunit α alpha (IL3RA or CD123) gene is localized in the X and Y chromosomes. It comprises a highly mobile N-terminal domain (NTD) region and fibronectin type III (FnIII) domain. CD123 is expressed on early hematopoietic cells and is a type I cytokine receptor.

Immunogen

Synthetic peptide of human interleukin 3 receptor, alpha (low affinity)

Biochem./physiol. Wirkung

Elevated expression of IL3RA is reported in chronic myeloid leukemia (CML).) It may serve as a therapeutic potential to treat acute myelogenous leukemia (AML).

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

C T Jordan et al.
Leukemia, 14(10), 1777-1784 (2000-10-06)
Recent studies suggest that the population of malignant cells found in human acute myelogenous leukemia (AML) arises from a rare population of leukemic stem cells (LSCs). LSCs have been documented for nearly all AML subtypes and have been phenotypically described
Prognostic relevance of CD123 expression in adult AML with normal karyotype.
Gina Jiang et al.
British journal of haematology, 188(1), 181-184 (2019-11-24)
M Joseph et al.
Journal of medical genetics, 33(11), 906-911 (1996-11-01)
Colony stimulating factor-2 receptor alpha (CSF2RA) and interleukin-3 receptor alpha (IL3RA), two genes from the chromosome Xp and Yp pseudoautosomal region (PAR), have been suggested as candidate genes for short stature in Turner syndrome. We report three girls with X;Y
Sophie E Broughton et al.
Nature communications, 9(1), 386-386 (2018-01-28)
The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is overexpressed in acute and chronic myeloid leukaemia progenitor cells. It belongs to the type I cytokine receptor family in which the α-subunits

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