SAB4300226

Anti-phospho-SNCA (pTyr¹³³) antibody produced in rabbit

affinity isolated antibody

• Synonym(e): Anti-MGC110988 antibody produced in rabbit, Anti-NACP antibody produced in rabbit, Anti-PARK1 antibody produced in rabbit, Anti-PARK4 antibody produced in rabbit, Anti-synuclein, alpha (non A4 component of amyloid precursor) antibody produced in rabbit
• MDL-Nummer: MFCD02095740
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: ~18 kDa
• Speziesreaktivität: human, rat, mouse
• Konzentration: 1 mg/mL
• Methode(n): indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• Isotyp: IgG
• Immunogene Sequenz: (E-G-YP-Q-D)
• NCBI-Hinterlegungsnummer: NP_000336.1
• UniProt-Hinterlegungsnummer: P37840
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pTyr133)
• Angaben zum Gen: human ... SNCA(6622)

Beschreibung

Immunogen

Peptide sequence around phosphorylation site of tyrosine 133 (E-G-Y(p)-Q-D), according to the protein SNCA.

Leistungsmerkmale und Vorteile

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Zielbeschreibung

SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons.

Physikalische Form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable