SAB4300105

Anti-phospho-HDAC8 (pSer³⁹) antibody produced in rabbit

affinity isolated antibody

• Synonym(e): Anti-HDACL1 antibody produced in rabbit, Anti-RPD3 antibody produced in rabbit, Anti-histone deacetylase 8 antibody produced in rabbit
• MDL-Nummer: MFCD02686596
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: ~42 kDa
• Speziesreaktivität: human
• Konzentration: 1 mg/mL
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200
• Isotyp: IgG
• Immunogene Sequenz: (R-A-SP-M-V)
• NCBI-Hinterlegungsnummer: NP_001159890.1
• UniProt-Hinterlegungsnummer: Q9BY41
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pSer39)
• Angaben zum Gen: human ... HDAC8(55869)

Beschreibung

Immunogen

Peptide sequence around phosphorylation site of serine 39 (R-A-S(p)-M-V), according to the protein HDAC8.

Leistungsmerkmale und Vorteile

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Zielbeschreibung

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC8 gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.

Physikalische Form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable