SAB4200551

Anti-MST1R antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonym(e): Anti-CD136, Anti-CDw136, Anti-MST1R variant RON30, Anti-MST1R variant RON62, Anti-Macrophage stimulating 1 receptor (c-met-related tyrosine kinase), Anti-PTK8, Anti-PTK8 protein tyrosine kinase 8, Anti-RON, Anti-RON variant E2E3, Anti-c-met-related tyrosine kinase, Anti-macrophage-stimulating protein receptor, Anti-p185-Ron
• UNSPSC-Code: 12352203
• NACRES: NA.44

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~170 kDa
• Speziesreaktivität: rat, human
• Konzentration: ~1.0 mg/mL
• Methode(n): western blot: 2.5-5.0 μg/mL using whole extracts of human HT-29 cells.
• UniProt-Hinterlegungsnummer: Q04912
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... MST1R(4486) ; rat ... Mst1r(300999)

Beschreibung

Allgemeine Beschreibung

Macrophage-stimulating protein receptor (MST1R) is a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. It is a heterodimer of disulfide-linked α- and β-subunits, generated by proteolytic cleavage of a single-chain precursor. MST1R is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung. It belongs to the MET receptor tyrosine kinase family. MST1R is located on the human chromosome at 3p21.31.

Spezifität

Anti-MST1R recognizes human MST1R.

Immunogen

synthetic peptide corresponding to an internal region of human MST1R, conjugated to KLH. The corresponding sequence is identical in rat and differs by 2 amino acids in mouse.

Anwendung

Anti-MST1R antibody produced in rabbit may be used in immunoblotting.

Biochem./physiol. Wirkung

Macrophage-stimulating protein receptor (MST1R) takes part in tumorigenesis. MST1R along with MSP is involved in host defense. Mutation of MST1R is associated with carcinoma of the breast, bladder, lung, colon, prostate, ovary and pancreas. Increased levels of MST1R is observed in aggressive tumors with poor patient survival.

Physikalische Form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Lagerung und Haltbarkeit

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Haftungsausschluss

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable