SAB4200179

Anti-Importin 5 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonym(e): Anti-IPO5
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~123 kDa
• Speziesreaktivität: human
• Konzentration: ~1.0 mg/mL
• Methode(n): immunoprecipitation (IP): 2.5-5.0 μg using lysates of human HEK-293 cells.; indirect immunofluorescence: 2.5-5.0 μg/mL using HEK-293 cells overexpressing human Importin 5.; western blot: 2-4 μg/mL using whole extracts of human Jurkat cells.
• UniProt-Hinterlegungsnummer: O00410
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... IPO5(3843) ; mouse ... Ipo5(70572) ; rat ... Ipo5(306182)

Beschreibung

Allgemeine Beschreibung

In human cells, there are more than 20 members of the importins/exportins family. Importin-5 (IPO5) belongs to the importin-β superfamily and is mapped to human chromosome 13q32.2.

Anwendung

Anti-Importin 5 (C-terminal) antibody produced in rabbit has been used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

Biochem./physiol. Wirkung

Nucleocytoplasmic transport of proteins and RNAs is mediated through nuclear pore complexes (NPCs) and by karyopherins nuclear transport receptors (importins/exportins). Importins mediate either the nuclear import of a very diverse set of protein or RNA cargoes. The function of importins are regulated by the Ran G protein. Ran G protein stimulates the release of cargo from importins. Importins are implicated in anti-aggregation activity of highly basic cargo like histones and ribosomal proteins and in preventing their undesired interactions with other cellular components.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable