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Merck

SAB2702316

Sigma-Aldrich

Monoclonal Anti-CEP152 antibody produced in mouse

clone GT1315, affinity isolated antibody

Synonym(e):

MCPH4, MCPH9, SCKL5

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

GT1315, monoclonal

Form

buffered aqueous solution

Mol-Gew.

189kDa

Speziesreaktivität

human

Konzentration

1mg/mL

Methode(n)

western blot: 1:500-1:3000

Isotyp

IgG1

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... CEP152(22995)

Allgemeine Beschreibung

CEP152 (centrosomal protein 152), a mammalian ortholog of Drosphila asterless is a component of mammalian centrosomes. It is located on human chromosome 15.

Immunogen

Recombinant protein encompassing a sequence within the N-terminus region of human CEP152.

Anwendung

Suggested starting dilutions are as follows: WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Biochem./physiol. Wirkung

This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq]
CEP152 (centrosomal protein 152) plays an important role in cell division and development. It is highly essential for the recruitment of centriole of Plk4 (polo-like kinase 4) and centriole duplication at the time of cell cycle.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Sonstige Hinweise

Purification: Affinity purified by Protein G

Physikalische Form

Phosphate-buffered saline, no preservative added.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4.
Guernsey DL, et al.
American Journal of Human Genetics, 87(1), 40-51 (2010)
Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.
Sonnen KF, et al.
Journal of Cell Science, 126(14), 3223-3233 (2013)
Primary autosomal recessive microcephaly: homozygosity mapping of MCPH4 to chromosome 15.
Jamieson CR, et al.
American Journal of Human Genetics, 65(5), 1465?1469-1465?1469 (1999)

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