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SAB1305415

Sigma-Aldrich

ANTI-MLCK(N-TERMINAL) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(e):

Myosin light chain kinase

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Antikörperform

IgG fraction of antiserum

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

210715 Da

Speziesreaktivität

human, mouse

Methode(n)

immunohistochemistry: 1:50-1:100
western blot: 1:1000

NCBI-Hinterlegungsnummer

NP_444253.3

UniProt-Hinterlegungsnummer

Q15746

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... MYLK(4638)

Allgemeine Beschreibung

Myosin light chain kinase (MLCK) is a serine/threonine kinase and the gene encoding it is localized on human chromosome 3q21.1.

Biochem./physiol. Wirkung

Myosin light chain kinase (MLCK) is activated by the binding of Ca2+/calmodulin. It has a role in smooth muscle contraction. The kinase phosphorylates the regulatory light chain of smooth muscle myosin. This stimulates ATPase activity of the myosin heads and leads to the myosin power stroke, which is crucial for muscle contraction. MLCK also assists the interaction of myosin with actin. Loss of function of the protein has been linked to megacystis microcolon intestinal hypoperistalsis syndrome.

Physikalische Form

Supplied in PBS with 0.09% (W/V) sodium azide

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Loss-of-Function Variants in MYLK Cause Recessive Megacystis Microcolon Intestinal Hypoperistalsis Syndrome.
Halim D
American Journal of Human Genetics (2017)
Increasing evidence of mechanical force as a functional regulator in smooth muscle myosin light chain kinase.
Baumann F
eLife (2017)
A novel variant in MYLK causes thoracic aortic dissections: genotypic and phenotypic description.
Hannuksela M
BMC Medical Genetics (2016)
Bingqing Bai et al.
Molecular medicine reports, 25(4) (2022-02-10)
Aberrant TGF‑β/Smad7 signaling has been reported to be an important mechanism underlying the pathogenesis of ulcerative colitis. Therefore, the present study aimed to investigate the effects of a number of potential anti‑colitis agents on intestinal epithelial permeability and the TGF‑β/Smad7

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