S8939

SGK1 (δ1-60, S422D), active human

recombinant, expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged), buffered aqueous solution

• MDL-Nummer: MFCD03458482
• UNSPSC-Code: 51111800
• NACRES: NA.32

Eigenschaften

• Rekombinant: expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged)
• Qualitätsniveau: 200
• Form: buffered aqueous solution
• Mol-Gew.: ~48 kDa by SDS-PAGE
• UniProt-Hinterlegungsnummer: O00141
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... SGK1(6446)

Beschreibung

Allgemeine Beschreibung

The serum- and glucocorticoid-regulated kinase (SGK1) is a member of the AGC kinase family and the gene encoding it is localized on human chromosome 6q23.

Biochem./physiol. Wirkung

The serum- and glucocorticoid-regulated kinase (SGK1) has a role in the hormonal regulation of ion channels and pumps. It has been associated with cancers. The protein modulates nitric oxide production by activating NO synthase. SGK1 protects cells from apoptosis and oxidative stress.

Kinase assays.

Einheitendefinition

One unit of SGK1 = 1 nmol phosphate incorporated into crosstide substrate peptide in one minute.

Physikalische Form

Solution in 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 0.15 M NaCl, 0.03% Brij^® L23, 1 mM benzamidine, 0.2 mM PMSF. and 270 mM sucrose.

Rechtliche Hinweise

Brij is a registered trademark of Croda International PLC

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids