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S6045
Anti-Stem Cell Factor antibody produced in goat
IgG fraction of antiserum, lyophilized powder
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About This Item
Biologische Quelle
goat
Qualitätsniveau
Konjugat
unconjugated
Antikörperform
IgG fraction of antiserum
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
lyophilized powder
Speziesreaktivität
mouse
Methode(n)
neutralization: suitable
Lagertemp.
−20°C
Angaben zum Gen
mouse ... Kitl(17311)
Allgemeine Beschreibung
Mast cells play an important role in innate immunity or the response of the body to invading pathogens. The functions of mast cells are regulated by a number of surface receptors; the receptors to Stem cell factor (SCF; c-Kit ligand or mast cell growth factor) being the most critical. The signalling triggered by SCF results in mast cell activation in response to antigens. The response involves tyrosine phosphorylation by specific tyrosine kinases that drive the downstream signalling process. The secondary pathways activated by SCF are signalling mediated by Akt, mTOR, MAPK and c-Jun. In addition to development of mast cells, SCF also regulates their subsequent maturation and homing to the residence sites. Constitutive activation by SCF is implicated in myeloproliferative discorders, systemic mastocytosis and gastrointestinal stomal cell tumors
Anti-Stem Cell Factor antibody reacts specifically with mouse stem cell factor.
Anti-Stem Cell Factor antibody reacts specifically with mouse stem cell factor.
Spezifität
The antibody will neutralize the biological activity of recombinant mouse SCF.
Immunogen
recombinant mouse SCF
Anwendung
Anti-Stem Cell Factor antibody may be used to neutralize SCF at a concentration of 25 ng/ml in 1X105/ml TF-1 cells. The antibody has been used to neutralize SCF in primary murine embryonic fibroblast (MEF) culture. The recommended concentration for indirect ELISA is 1.0 μg/ml and for immunoblotting is 2.0 μg/ml.
Physikalische Form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline
Angaben zur Herstellung
Purified using protein G
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor
Tsai M et al
Proceedings of the National Academy of Sciences of the USA, 15, 6382-6386 (1991)
Hui Hua Zhang et al.
Journal of leukocyte biology, 82(4), 915-925 (2007-07-27)
G-CSF and GM-CSF play important roles in regulating neutrophil production, survival, differentiation, and function. However, we have shown previously that G-CSF/GM-CSF double-deficient [knockout (KO)] mice still develop a profound neutrophilia in bone marrow and blood after infection with Candida albicans.
Y Kitamura et al.
International archives of allergy and immunology, 107(1-3), 54-56 (1995-05-01)
Signaling through the c-kit receptor tyrosine kinase (Kit) is essential for development and survival of mast cells but not of basophils. Moreover, we recently found an activation mutation of Kit in several tumor mast cell lines.
Shoko Iwaki et al.
The Journal of biological chemistry, 280(48), 40261-40270 (2005-09-24)
Stem cell factor (SCF) acts in synergy with antigen to enhance the calcium signal, degranulation, activation of transcription factors, and cytokine production in human mast cells. However, the underlying mechanisms for this synergy remain unclear. Here we show, utilizing bone
Juan Rivera et al.
The Journal of allergy and clinical immunology, 117(6), 1214-1225 (2006-06-06)
The mast cell is a central player in allergy and asthma. Activation of these cells induces the release of preformed inflammatory mediators localized in specialized granules and the de novo synthesis and secretion of cytokines, chemokines, and eicosanoids. The balance
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