This product is lyophilized from a solution containing sodium glutamate and human serum albumin. The material may be reconstituted in water. For assay purposes, this material is reconstituted in 10 mM Tris-HCl / 0.1 M NaCl / 0.1% BSA, pH 7.4 . The solution stability has not been determined.
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Streptokinase aus beta;-haemolytischer Streptococcus (Lancefield Gruppe C)
lyophilized powder, ≥2,000 units/mg solid
Synonym(e):
Streptokinase from Streptococcus hemolyticus
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10000 UNITS
CHF 67.10
50000 UNITS
CHF 216.00
250000 UNITS
CHF 667.00
About This Item
CHF 67.10
Check Cart for Availability
Empfohlene Produkte
Form
lyophilized powder
Spezifische Aktivität
≥2,000 units/mg solid
Versandbedingung
wet ice
Lagertemp.
−20°C
SMILES String
N1C(CC(C1)C2CCCCC2)C(=O)O
InChI
1S/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,1-7H2,(H,13,14)
InChIKey
XRZWVSXEDRYQGC-UHFFFAOYSA-N
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Allgemeine Beschreibung
Research area: Cell signaling
Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.[1]
Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.[1]
Anwendung
Streptokinase has been used in a study to compare primary coronary intervention and thrombolytic therapy in myocardial infarction patients. [2]
Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare.
Biochem./physiol. Wirkung
Streptokinase is a potent plasminogen activator. Unlike human proteins tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), microbial streptokinase does not directly activate plasminogen. Instead, it activates plasminogen by fibrin-dependent and fibrin-independent. mechanisms.[1] Streptokinase is effective in thrombolytic therapy.[1] While streptokinase offers promising potential in treating ischemic stroke, its use also presents a significant risk of intracerebral hemorrhage. Streptokinase is also used in treating complicated parapneumonic effusions and empyema where allergic reactions, are rare.[3]
Einheitendefinition
One unit is equal to the amount of activity in one unit from a Streptokinase International Standard reference vial.
Physikalische Form
Lyophilized powder containing ~50% total protein by biuret and sodium glutamate. Total protein composed of enzyme protein and human serum albumin.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Kunden haben sich ebenfalls angesehen
Streptokinase--a clinically useful thrombolytic agent
Banerjee A, et al.
Biotechnology Advances, 22(4), 287-307 (2004)
Streptokinase--a clinically useful thrombolytic agent
Banerjee A, et al.
Biotechnology Advances, 22(4), 2004-2004 (2004)
Staphylokinase, a fibrin-specific plasminogen activator with therapeutic potential?
D Collen et al.
Blood, 84(3), 680-686 (1994-08-01)
Primary coronary intervention versus thrombolytic therapy in myocardial infarction patients in the Middle East
Al-Zakwani, I., et al.
Journal of the American Medical Association, 34(3), 445-451 (2012)
Role of streptokinase in the treatment of acute loculated parapneumonic pleural effusions and empyema
Bouros D, et al.
Thorax, 49(9), 852-855 (1994)
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