immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:5,000 using human colon adenocarcinoma tissue microarray: suitable western blot: 1:100 using human acute lymphoma Jurkat cell lysate
This sequence recognized by the antibody is highly conserved across species (e.g., mouse, rat p105 Rb) and is not found in p107 Rb and p130 Rb.
Immunogen
synthetic peptide corresponding to amino acids 914-928 of the C-terminal region of human p105 retinoblastoma protein (p105 Rb) with N-terminally added cysteine, conjugated to maleimide-activated KLH.
Physikalische Form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular and cellular biology, 24(16), 7260-7274 (2004-07-30)
Transcriptional activation of the cyclin D1 gene (CCND1) plays a pivotal role in G(1)-phase progression, which is thereby controlled by multiple regulatory factors, including nuclear receptors (NRs). Appropriate CCND1 gene activity is essential for normal development and physiology of the
A water-soluble formulation of CoQ10 (WS-CoQ10) was shown to stabilize mitochondria and prevent oxidative stress-induced neuronal death. Presenilin-1 (PS-1)-mutated Alzheimer's Disease (AD) fibroblasts (PSAF) were used for studying the effects of PS-1 mutation. PS-1 mutation correlated to increased reactive oxygen
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