P3493

Monoclonal Anti-Placenta Growth Factor-2 antibody produced in rat

clone 62526, purified immunoglobulin, lyophilized powder

• Synonym(e): Anti-PlGF-2
• MDL-Nummer: MFCD02097209
• UNSPSC-Code: 51111800
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rat
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 62526, monoclonal
• Form: lyophilized powder
• Speziesreaktivität: mouse
• Methode(n): indirect ELISA: 0.5-1.0 μg/mL; neutralization: suitable; western blot: 1-2 μg/mL
• Isotyp: IgG2a
• UniProt-Hinterlegungsnummer: P49764
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: mouse ... Pgf(18654)

Beschreibung

Allgemeine Beschreibung

The antibody neutralizes receptor-ligand interaction. The antibody shows no cross-reactivity with recombinant human PlGF and recombinant human VEGF.

Immunogen

purified recombinant mouse placenta growth factor 2 expressed in insect Sf 21 cells.

Biochem./physiol. Wirkung

Placental growth factors (PlGF) are involved in the growth, migration and survival of endothelial cells. All the four isoforms identified are expressed in placenta and umbilical vein endothelial cells. PlGF bind to specific Flt-1 receptors that result in activation and recruitment of dendritic cells, smooth muscle cells and inflammatory cells. PlGF2 has the ability to bind heparin while PlGF1 is a soluble isoform.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline with 5% trehalose.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)