Direkt zum Inhalt
Merck

Wichtige Dokumente

Gesamtdokumentation anzeigen

P119

(±)-Pindobind

solid

Synonym(e):

N8-Bromoacetyl-N1-3′-(4-indolyloxy)-2′-hydroxy-propyl-(Z)-1,8-diamino-p-menthane

Anmelden zur Ansicht der Organisations- und Vertragspreise.

Größe auswählen

Ansicht ändern

Über diesen Artikel

Empirische Formel (Hill-System):
C23H34BrN3O3
CAS-Nummer:
106469-51-6
Molekulargewicht:
480.44
UNSPSC Code:
12352103
MDL number:
MFCD00082321
Technischer Dienst
Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.
Unterstützung erhalten

form

solid

color

white

solubility

DMSO: soluble, ethanol: soluble, methanol: soluble

storage temp.

−20°C

Biochem/physiol Actions

Analog of pindolol that contains a bromo-acetyl group capable of alkylating β-adrenergic receptors; easily radioiodinated.

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Dokumente section.

Wenn Sie Hilfe benötigen, wenden Sie sich bitte an Kundensupport

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

J Pitha et al.
Journal of medicinal chemistry, 30(4), 612-615 (1987-04-01)
New alkylating ligands derived from indole with high affinity for beta-adrenoceptors were synthesized and their properties examined. N8-(Bromoacetyl)-N1-[3-(4-indolyloxy)-2-hydroxypropyl]-(Z)-1,8-dia mino-p- menthane (8) and its N1,N8 isomer (9) were prepared by the reaction of bromoacetyl bromide with a product of the condensation
P Molenaar et al.
Biochemical pharmacology, 37(19), 3601-3607 (1988-10-01)
The actions of alkylating pindolol (N8-bromoacetyl-N1-3'-(4-indolyloxy)-2'-hydroxypropyl[z]-1,8- diamino-p-menthane; BIM) have been examined on beta-adrenoceptors in guinea-pig left atria and trachea. In organ bath experiments, addition of BIM (greater than or equal to 0.1 microM), followed by washout, produced concentration-dependent rightward shifts
R J Box
Journal of receptor research, 9(4-5), 385-403 (1989-01-01)
The reactivities with beta-adrenergic receptors of the bromoacetyl derivatives of the beta-adrenergic antagonists alprenolol and pindolol, BAAM and BIM, respectively, were compared in intact S49 mouse lymphoma cells. Both compounds caused irreversible blockade of receptors and changes in the mobility