Direkt zum Inhalt
Merck
Alle Fotos(1)

Key Documents

View All Documentation

P1123

Sigma-Aldrich

PD 81,723

≥98% (HPLC), solid

Synonym(e):

(2-Amino-4,5-dimethyl-3-thienyl)-[3-(trifluoromethyl)phenyl]methanone

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

Empirische Formel (Hill-System):
C14H12F3NOS
CAS-Nummer:
132861-87-1
Molekulargewicht:
299.31
MDL-Nummer:
MFCD01321053
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329820073

Assay

≥98% (HPLC)

Form

solid

Lagerbedingungen

protect from light
under inert gas

Farbe

yellow

Löslichkeit

DMSO: ~13 mg/mL
H2O: insoluble

Lagertemp.

−20°C

SMILES String

Cc1sc(N)c(c1C)C(=O)c2cccc(c2)C(F)(F)F

InChI

1S/C14H12F3NOS/c1-7-8(2)20-13(18)11(7)12(19)9-4-3-5-10(6-9)14(15,16)17/h3-6H,18H2,1-2H3

InChIKey

KKDKAWKYGCUOGR-UHFFFAOYSA-N

Suchen Sie nach ähnlichen Produkten? Aufrufen Leitfaden zum Produktvergleich

Biochem./physiol. Wirkung

Allosteric enhancer of A1 adenosine receptors

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Daniele Pietra et al.
Journal of theoretical biology, 267(4), 663-675 (2010-08-31)
A new mathematical model, referred to as Enhancer and Competitive Allosteric Modulator (ECAM) model, developed with the aim of quantitatively describing the interaction of an allosteric modulator with both enhancer and competitive properties towards G-protein-coupled receptors is described here. Model
D M Dennis et al.
Circulation, 94(10), 2551-2559 (1996-11-15)
There has been increasing interest in the development of agents that utilize endogenous adenosine to exert their actions. We tested the hypothesis that substances that either potentiate the activity (allosteric enhancers) or increase the interstitial concentration (inhibitors of metabolism) of
Jianzhong Shen et al.
Circulation research, 96(9), 982-990 (2005-04-16)
Adenosine is a vascular endothelial cell mitogen, but anti-mitogenic for aortic smooth muscle cells and fibroblasts when acting via the A2B adenosine receptor. However, we show that adenosine increases porcine coronary artery smooth muscle cell (CASMC) number, cellular DNA content
M C Peeters et al.
Biochemical pharmacology, 84(1), 76-87 (2012-03-28)
The adenosine A1 receptor is a member of the large membrane protein family that signals through G proteins, the G protein-coupled receptors (GPCRs). GPCRs consist of seven transmembrane domains connected by three intracellular and three extracellular loops. Their N-terminus is
B Brandts et al.
British journal of pharmacology, 121(6), 1217-1223 (1997-07-01)
1. PD 81,723 has been shown to enhance binding of adenosine to A1 receptors by stabilizing G protein-receptor coupling ('allosteric enhancement'). Evidence has been provided that in the perfused hearts and isolated atria PD 81,723 causes a sensitization to adenosine
Alle zugehörigen Dokumente anzeigen

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.