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Merck

N5912

Sigma-Aldrich

Anti-NORE1 (RASSF5) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-RAPL, Anti-Ras Association (RalGDS/AF-6) Domain Family 5

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

mouse, rat, human

Methode(n)

western blot: 1:500-1:1,000

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... RASSF5(83593)
mouse ... Rassf5(54354)
rat ... Rassf5(54355)

Allgemeine Beschreibung

Ras association domain family member 5 (RASSF5) is also known as novel Ras effector- 1 (NORE-1). It exists in three isoforms and the gene encoding it is located on human chromosome 1q32.1.

Immunogen

peptide corresponding to the NORE1 protein (amino acids 313-329). This sequence is located in the RA domain of NORE1 and is 100% conserved between human, mouse, rat, and hamster.

Biochem./physiol. Wirkung

Ras association domain family member 5 (RASSF5) is a tumor suppressor protein. It interacts with kinases like mammalian sterile 20-like kinase 1/2 (MST1/2). RASSF5 is involved in the regulation of cell cycle and apoptosis.

Physikalische Form

Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Xu-Hui Zhou et al.
Oncology reports, 32(4), 1505-1512 (2014-08-12)
Ras association (RalGDS/AF-6) domain family member RASSF5 has been implicated in a variety of key biological processes, including cell proliferation, cell cycle regulation and apoptosis. It is believed to play an important role in tumorigenesis as a tumor suppressor in
Katherine K Slemmons et al.
Cancer research, 80(14), 3046-3056 (2020-05-02)
Rhabdomyosarcoma is the most common childhood soft-tissue sarcoma, yet patients with metastatic or recurrent disease continue to do poorly, indicating a need for new treatments. The SRC family tyrosine kinase YES1 is upregulated in rhabdomyosarcoma and is necessary for growth
Hye Jin Kim et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 68(Pt 7), 813-815 (2012-07-04)
NORE1 is an important tumour suppressor in human cancers that interacts with the pro-apoptotic protein kinase MST1/2 through SARAH domains. The SARAH domain (residues 366-413) of human NORE1 was expressed in Escherichia coli, purified and crystallized using the hanging-drop vapour-diffusion
Xiaoli Liu et al.
Frontiers in oncology, 10, 600927-600927 (2021-01-26)
The principal issue derived from thyroid cancer is its high propensity to metastasize to the lymph node. Aberrant exprssion of long non-coding RNAs have been extensively reported to be significantly correlated with lymphatic metastasis of thyroid cancer. However, the clinical
Wei Guo et al.
Clinical & experimental metastasis, 32(1), 83-98 (2015-01-13)
As a result of alternative splicing and differential promoter usage, RASSF5 exists in at least three isoforms (RASSF5A-RASSF5C), which may play different roles in tumorigenesis. The present study was to detect the role of RASSF5A, B and C in esophageal

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