M005
S-(+)-Deprenyl hydrochloride
solid
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Empirische Formel (Hill-System):
C13H17N · HCl
CAS-Nummer:
Molekulargewicht:
223.74
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Technischer Dienst
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Unterstützung erhaltenform
solid
optical activity
[α]24/D +11.84°, c = 0.1 in H2O(lit.)
color
white
solubility
H2O: soluble
SMILES string
Cl.C[C@@H](Cc1ccccc1)N(C)CC#C
Biochem/physiol Actions
Less active enantiomer of deprenyl.
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Verwandter Inhalt
J W Tetrud et al.
Science (New York, N.Y.), 245(4917), 519-522 (1989-08-04)
The effects of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), a neurotoxin that produces the symptoms of Parkinson's disease, can be fully prevented in experimental animals by inhibiting monoamine oxidase B. On the basis of this observation, a double-blind, placebo-controlled study in patients with early
Keiko Inaba-Hasegawa et al.
Journal of neural transmission (Vienna, Austria : 1996), 120(3), 435-444 (2012-09-13)
Type B monoamine oxidase (MAO-B) is proposed to be involved in the pathogenesis of neurodegenerative disorders, such as Parkinson's disease, through oxidative stress and synthesis of neurotoxins. MAO-B inhibitors, rasagiline and selegiline [(-)deprenyl], protect neuronal cells by direct intervention in
Chitra Sridar et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(12), 2256-2266 (2012-09-01)
Selegiline, the R-enantiomer of deprenyl, is used in the treatment of Parkinson's disease. Bupropion, an antidepressant, often used to treat patients in conjunction with selegiline, is metabolized primarily by CYP2B6. The effect of selegiline on the enzymatic activity of human