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Ursprungszeugnis (CoO)/Analysenzertifikate (CoA)

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L2400

Lavendustin A

Name: Lavendustin A
Brand: SIGMA

~85% (TLC), crystalline

Synonym(e):

5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid

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About This Item

Empirische Formel (Hill-System):

C₂₁H₁₉NO₆

CAS-Nummer:

125697-92-9

Molekulargewicht:

381.38

MDL-Nummer:

MFCD00153822

UNSPSC-Code:

12352200

PubChem Substanz-ID:

24896314

Assay

~85% (TLC)

Form

crystalline

Löslichkeit

DMSO: soluble
methanol: soluble

Lagertemp.

−20°C

SMILES String

OC(=O)c1cc(ccc1O)N(Cc2ccccc2O)Cc3cc(O)ccc3O

InChI

1S/C21H19NO6/c23-16-6-8-19(25)14(9-16)12-22(11-13-3-1-2-4-18(13)24)15-5-7-20(26)17(10-15)21(27)28/h1-10,23-26H,11-12H2,(H,27,28)

InChIKey

ULTTYPMRMMDONC-UHFFFAOYSA-N

Angaben zum Gen

human ... EGFR(1956) , ERBB2(2064) , LCK(3932)

Biochem./physiol. Wirkung

Cell-permeable tyrosine kinase inhibitor with little effect on protein kinase A or C. Inhibits NMDA-stimulated cGMP production. Inhibits VEGF-induced angiogenesis.

Physikalische Form

Photosensitive

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Protein tyrosine kinase is required for the induction of long-term potentiation in the rat hippocampus.

C C Huang et al.

The Journal of physiology, 520 Pt 3, 783-796 (1999-11-02)

1. Protein tyrosine phosphorylation is thought to play an important role in the regulation of neuronal function. Previous work has shown that protein tyrosine kinase (PTK) inhibitors can inhibit the induction of long-term potentiation (LTP), a candidate synaptic mechanism involved

Modulation of AMPA excitatory postsynaptic currents in the spinal cord dorsal horn neurons by insulin.

D Spicarova et al.

Neuroscience, 166(1), 305-311 (2009-12-17)

Glutamate AMPA receptors are critical for sensory transmission at the spinal cord dorsal horn (DH). Plasma membrane AMPA receptor endocytosis that can be induced by insulin may underlie long term modulation of synaptic transmission. Insulin receptors (IRs) are known to

Influence of the tyrosine kinase inhibitors STI571 (Glivec), lavendustin A and genistein on human mast cell line (HMC-1(560)) activation.

Kristin Löber et al.

Journal of cellular biochemistry, 103(4), 1076-1088 (2007-07-31)

The human mast cell line (HMC-1(560)) was used to study the effects of tyrosine kinase (TyrK) inhibition on histamine release in consequence of intracellular Ca2+ or pH changes. This is important since the TyrK inhibitor STI571 (Glivec) inhibits proliferation and

Effects of monocarboxylic acid-derived Cl- channel blockers on depolarization-activated potassium currents in rat ventricular myocytes.

Shi-Sheng Zhou et al.

Experimental physiology, 92(3), 549-559 (2007-02-17)

The effects of monocarboxylic acid-derived Cl(-) channel blockers on cardiac depolarization-activated K(+) currents were investigated. Membrane currents in rat ventricular myocytes were recorded using the whole-cell configuration of the patch-clamp technique. 5-Nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) and niflumic acid (NFA) induced an

Inhibition of atrial wall stretch-induced cardiac hormone secretion by lavendustin A, a potent tyrosine kinase inhibitor.

P Taskinen et al.

Endocrinology, 140(9), 4198-4207 (1999-08-28)

The cellular processes linking mechanical wall stretch to atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) secretion from the heart are unclear. In the present study, a paced perfused rat heart preparation was used to study the signaling mechanisms

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