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Merck

I8026

Sigma-Aldrich

Anti-Interleukin-8 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym(e):

Anti-CXCL8

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About This Item

MDL-Nummer:
UNSPSC-Code:
51111800
NACRES:
NA.41

Biologische Quelle

goat

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

lyophilized powder

Speziesreaktivität

human

Methode(n)

immunocytochemistry: 5-15 μg/mL
immunohistochemistry: 5-15 μg/mL
neutralization: suitable
western blot: 0.1 μg/mL

Lagertemp.

−20°C

Angaben zum Gen

human ... IL8(3576)

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Allgemeine Beschreibung

Interleukin 8 (IL-8) is an 8kD, 72 amino acid residue containing cytokine that belongs to C-X-C chemokine family . The IL-8 gene is mapped to human chromosome 4q13.3.

Spezifität

The antibody will neutralize the biological activity of recombinant and natural human IL-8, but not recombinant human GROα.

Immunogen

recombinant human IL-8 (CXCL8).

Anwendung

Anti-Interleukin-8 antibody can be used for the following :
  • For neutralizing the biological activity of recombinant human IL-8 and natural human IL-8.
  • Immunoblotting.
  • ELISA.
Anti-Interleukin-8 antibody can be used in immunocytochemistry and immunohistochemistry.

Biochem./physiol. Wirkung

Interleukin 8 (IL-8) stimulates neutrophils to produce lysosomal enzymes along with myeloperoxidase, α-mannosidase and β-glucuronidase . Goat anti-Interleukin-8 antibody reacts specifically with recombinant and natural human IL-8 but not with recombinant human GROα. Elevated expression of the gene is observed in a number of cancers including chronic spontaneous urticaria and breast cancer, thus serves as a prognostic marker for the same. IL-8 regulates the metastasis and angiogenesis processes during cancer development. IL-8 is responsible for epithelial–mesenchymal transition which plays an important role in providing cancer cells the mobility to invade other neighbouring cells, thereby contributing to metastasis.

Physikalische Form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Identification and validation of vesicant therapeutic targets using a high-throughput siRNA screening approach.
Ruff A L, et al.
Archives of Toxicology, 90(2), 375-383 (2016)
Properties of pro-inflammatory cell type-specific leukocyte chemotactic cytokines, interleukin 8 (IL-8) and monocyte chemotactic and activating factor (MCAF).
N Mukaida et al.
Microbiology and immunology, 36(8), 773-789 (1992-01-01)
Elevated plasma il-8 concentration is related to severity of systemic inflammation in chronic spontaneous urticaria.
Kasperska-Zajac A, et al.
Journal of Biological Regulators and Homeostatic Agents, 31(4), 957-961 (2017)
T Yoshimura et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(24), 9233-9237 (1987-12-01)
Stimulated human monocytes release several proteins thought to play a role in inflammation, including interleukin 1, tumor necrosis factor, and plasminogen activator. We have purified another proinflammatory protein that is chemotactic for human neutrophils from conditioned medium of lipopolysaccharide-stimulated monocytes.
Sohlh2 suppresses epithelial to mesenchymal transition in breast cancer via downregulation of IL-8.
Ji S, et al.
Oncotarget, 7(31), 49411-49411 (2016)

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